10 Result(s)

Article

EBMT prospective observational study on allogeneic hematopoietic stem cell transplantation in T-prolymphocytic leukemia (T-PLL)

Preliminary data suggest that allogeneic stem cell transplantation (allo-SCT) may be effective in T-prolymphocytic leukemia (T-PLL). The purpose of the present observational study was to assess the outcome of ...

W. Wiktor-Jedrzejczak, J. Drozd-Sokolowska, D. J. Eikema… in Bone Marrow Transplantation (2019)

Article

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. The median...

E I Andersson, S Pützer, B Yadav, O Dufva, S Khan, L He, L Sellner, A Schrader… in Leukemia (2018)

Article

GvL effects in T-prolymphocytic leukemia: evidence from MRD kinetics and TCR repertoire analyses

Allogeneic stem cell transplantation (alloSCT) is used for treating patients with T-prolymphocytic leukemia (T-PLL). However, direct evidence of GvL activity in T-PLL is lacking. We correlated minimal residual...

L Sellner, M Brüggemann, M Schlitt, H Knecht, D Herrmann… in Bone Marrow Transplantation (2017)

Article

Dissection of CD20 regulation in lymphoma using RNAi

M Słabicki, K S Lee, A Jethwa, L Sellner, F Sacco, T Walther, J Hüllein… in Leukemia (2016)

Article

Thiotepa-based high-dose therapy for autologous stem cell transplantation in lymphoma: a retrospective study from the EBMT

Clinical information about thiotepa-based autologous stem cell transplantation (auto-SCT) outside the primary central nervous system lymphoma (PCNSL) field is sparse. In this registry-based retrospective study...

L Sellner, A Boumendil, H Finel, S Choquet, G de Rosa… in Bone Marrow Transplantation (2016)

Article

p53-dependent non-coding RNA networks in chronic lymphocytic leukemia

Mutations of the tumor suppressor p53 lead to chemotherapy resistance and a dismal prognosis in chronic lymphocytic leukemia (CLL). Whereas p53 targets are used to identify patient subgroups with impaired p53 ...

C J Blume, A Hotz-Wagenblatt, J Hüllein, L Sellner, A Jethwa, T Stolz… in Leukemia (2015)

Article

Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton

Chronic lymphocytic leukemia (CLL) is an incurable malignancy of mature B cells. One of the major challenges in treatment of CLL is the achievement of a complete remission to prevent relapse of disease origina...

P B Knudsen, B Hanna, S Ohl, L Sellner, T Zenz, H Döhner, S Stilgenbauer… in Leukemia (2014)

Article

What Do We Do with Chronic Lymphocytic Leukemia with 17p Deletion?

Chronic lymphocytic leukemia (CLL) with 17p deletion or mutations of the TP53 gene has a very poor outcome. Optimal treatment of these patients remains a major clinical challenge, and disagreement on the optimal ...

L. Sellner, S. Denzinger, S. Dietrich, H. Glimm… in Current Hematologic Malignancy Reports (2013)