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Article
Replantation versus transplantation: Where do we stand?
Despite advances in extremity trauma care and reconstructive microsurgery, management of the traumatic amputations remains a challenge. The majority of patients will forever experience some level of disability...
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Chapter
Hand Allotransplantation: The Penn Experience
The Penn Hand Transplant Program is based at the University of Pennsylvania and has successfully performed four bilateral upper extremity vascularized composite allograft transplantations since its inception i...
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Chapter
Hand Transplantation in Children
Pediatric hand transplantation is a recent addition to the field of vascularized composite allotransplantation. After careful patient selection, thorough preoperative planning, and repeated rehearsals by a lar...
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Chapter
Soft Tissue Coverage for the Hand and Upper Extremity
Soft tissue coverage of the hand and upper extremity is an essential component of restoring function during extremity reconstruction. Function of the hand and upper extremity is critical to allow individuals t...
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Chapter
Lower Extremity Reconstruction: Local Flaps, Free Tissue Transfers
The senior author (LSL) first described the collaborative orthoplastic approach between orthopedic and plastic surgeons in the early 1990s, with regard to limb reconstruction. The goals of limb salvage are to ...
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Chapter
Ulnar Artery
This chapter describes the anatomy and surgical exposure of the ulnar artery and its branches in the forearm and hand for use as a recipient vessel in microsurgical reconstruction.
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Chapter
Recipient Vessels: Tibia Reconstruction
The free fibula is an effective option for reconstructing large and segmental defects of the tibia. This chapter describes the use of the vascularized free fibula flap and potential recipient vessels. Applied ...
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Chapter
Microsurgical Reconstruction of the Mangled Limb
The mangled extremity that sustains limb-threatening trauma is a challenging condition to manage. Significant tissue defects of the mangled limb result in exposed vital structures such as bone, nerves, vessels...
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Chapter
Radial Artery
This chapter describes the anatomy and surgical exposure of the radial artery and its branches in the forearm and hand for use as a recipient vessel in microsurgical reconstruction.
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Article
Open AccessDonor bone-marrow CXCR4+ Foxp3+ T-regulatory cells are essential for costimulation blockade-induced long-term survival of murine limb transplants
Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance immunosuppression was n...
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Chapter
Introduction to Lower Extremity Reconstruction: Historical Perspectives, Advances in the Field, and the Future
Reconstruction of the lower extremity has evolved as a separate discipline within reconstructive surgery. Trauma is the most common etiology for lower extremity wounds that require reconstruction, followed by ...
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Article
The safety and efficacy of magnetic targeting using autologous mesenchymal stem cells for cartilage repair
A new cell delivery system using magnetic force, termed magnetic targeting, was developed for the accumulation of locally injected cells in a lesion. The aim of this study was to assess the safety and efficacy...
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Article
Pediatric Vascular Composite Allograft Transplantation: Medical Considerations
This report summarizes recent medical findings in the case of an allogenic bilateral hand-forearm allotransplantation in a previously immunocompromised child and discusses the implications for expanding vascul...
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Chapter
Hand and Wrist Fractures in the Elderly
Distal radius fractures are among the most common fractures sustained by elderly individuals. As the population ages and elderly individuals continue to remain active, prevention and treatment of hand and wris...
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Article
Technology and vascularized composite allotransplantation (VCA)—lessons learned from the first bilateral pediatric hand transplant
The reconstructive principle of replacing “like with like” is best met with vascularized composite allotransplantation in which the components of an existing defect are “matched” to the greatest extent possibl...
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Article
Vascularized Composite Tissue Allografts (VCA): the Policy Side
In July 2013, the Secretary of Health amended the National Organ Transplant Act of 1986 to designate vascularized composite tissue allografts (VCAs) as organs. The definition of a VCA as an organ required that...
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Article
Evaluation of content and accessibility of hand fellowship websites
Graduates of general, orthopedic, and plastic surgery residencies utilize web-based resources when applying for hand fellowship training. The purpose of this study was to evaluate the accessibility and content...
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Reference Work Entry In depth
Traumatic Athletic Injuries of the Hand
The hand is critical for successful athletic participation in all but the rarest of circumstances. Despite the importance of the hands to the success of an athlete, they are often underemphasized in training a...
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Reference Work Entry In depth
Common Soft Tissue Injuries of the Hand
The hand is critical for successful athletic participation in all but the rarest of circumstances. Despite the importance of the hands to the success of an athlete, they are often underemphasized in training a...
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Article
Open AccessReduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model
Osteoarthritis (OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor (EGFR) signaling as an important reg...
