20 Result(s)

Article

Effect of nitrogen source and nickel concentration on green microalga Botryococcus braunii growth and its remediation potential

The effects of NO₃⁻ and/or NH₄⁺, and nickel on the growth and photosynthesis-respiration metabolism of Botryococcus braunii were analyzed. NO₃⁻, NH₄⁺ and Ni(II) removal capacity are described in terms of metaboli...

M. M. Areco, L. Rojas, D. G. Noseda, V. Passucci… in Journal of Applied Phycology (2022)

Article

A comprehensive analysis of factors related to carmustine/bevacizumab response in recurrent glioblastoma

Patients with recurrent glioblastoma (rGBM) have a poor prognosis, with survival ranging from 25 to 40 weeks. Antiangiogenic agents are widely used, showing a variable response. In this study, we explored the ...

A. F. Cardona, L. Rojas, B. Wills, A. Ruiz-Patiño… in Clinical and Translational Oncology (2019)

Article

Impact of NADPH oxidase functional polymorphisms in acute myeloid leukemia induction chemotherapy

Efficacy and toxicity of anthracycline treatment in acute myeloid leukemia (AML) is mediated by reactive oxygen species (ROS). NADPH oxidase is the major endogenous source of ROS and a key mediator of oxidativ...

J E Megías-Vericat, P Montesinos, M J Herrero, F Moscardó… in The Pharmacogenomics Journal (2018)

Article

Positive impact of ABCB1 polymorphisms in overall survival and complete remission in acute myeloid leukemia: a systematic review and meta-analysis

J E Megías-Vericat, L Rojas, M J Herrero, V Bosó… in The Pharmacogenomics Journal (2016)

Article

A systematic review and meta-analysis of the impact of WT1 polymorphism rs16754 in the effectiveness of standard chemotherapy in patients with acute myeloid leukemia

The polymorphism rs16754 of the WT1 gene has been described as a possible prognostic marker in different acute myeloid leukemia (AML) cohorts; however, it is not supported by all the studies. We performed the fir...

J E Megías-Vericat, M J Herrero, L Rojas, P Montesinos… in The Pharmacogenomics Journal (2016)

Article

Fine-map** butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection

Host–viral genetic interaction has a key role in hepatitis C infection (HCV) and maybe in the viral selection. In a preliminary GWAS analysis, we identified BTN3A2 rs9104 to be associated with HCV genotype 1. ...

J Ampuero, J A del Campo, L Rojas, R J García-Lozano, M Buti, R Solá… in Genes & Immunity (2015)

Article

Influence of ABCB1 polymorphisms upon the effectiveness of standard treatment for acute myeloid leukemia: A systematic review and meta-analysis of observational studies

The ABCB1 gene encodes for P-glycoprotein (P-gp), an efflux pump for a variety of xenobiotics. The role of ABCB1 polymorphisms in acute myeloid leukemia (AML) outcomes of standard chemotherapy (cytarabine plus...

J E Megías-Vericat, L Rojas, M J Herrero, V Bosó… in The Pharmacogenomics Journal (2015)

Article

Effect of CYP3A5*3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies

The highly variable pharmacokinetics of tacrolimus can hamper the optimal management of kidney transplant patients. This variability has been attributed to the genetic polymorphism of CYP3A5 6986A>G, but the evid...

L Rojas, I Neumann, M José Herrero, V Bosó, J Reig… in The Pharmacogenomics Journal (2015)

Chapter and Conference Paper

Characterizing the Expression Stability in Different Phenotypes of Recombinant NS0 Myeloma Cell Lines

The loss of heterologous protein expression is one of the major problems faced by industrial cell line developers and have been reported by several authors. For this reason understanding the mechanisms involve...

Y. Prieto, L. Rojas, L. Hinojosa… in Proceedings of the 21st Annual Meeting of … (2012)

Article

Towards the molecular characterization of the stable producer phenotype of recombinant antibody-producing NS0 myeloma cells

The loss of heterologous protein expression is one of the major problems faced by industrial cell line developers and has been reported by several authors. Therefore, the understanding of the mechanisms involv...

Y. Prieto, L. Rojas, L. Hinojosa, I. González, D. Aguiar, K. de la Luz… in Cytotechnology (2011)

Chapter and Conference Paper

Semi-Continuous Cultures as a Tool for Cell Line Characterization During Process Development

Although continuous cultures (CC) studies has been recognized as the standard method for cell line characterization, thorough and precise studies makes its use prohibitively costly. Batch cultures have also be...

S. Victores, A. Castillo, E. Faife, Y. Rabasa, Y. Alvarez, L. Rojas… in Cells and Culture (2010)

Article

Antibody seroprevalences against rabies in dogs vaccinated under field conditions in Bolivia

Bolivia currently has one of the highest numbers of cases for human and canine rabies and is thus clue to the elimination process. The objective of the present study was to assess antibody seroprevalences agai...

K. Suzuki, M. R. Pecoraro, A. Loza, M. Pérez… in Tropical Animal Health and Production (2008)

Article

Hopper (Homoptera: Auchenorrhyncha) diversity in shaded coffee systems of Turrialba, Costa Rica

Diversity of hopper species (suborder Auchenorryncha) in coffee (Coffea arabica) plantations with no shade (C) was compared with the diversity in plantations with shade of either poró (Erythrina poeppigiana) (CP)...

L. Rojas, C. Godoy, P. Hanson, C. Kleinn, L. Hilje in Agroforestry Systems (2001)

Chapter

Adaptation and Selection of NSO Myeloma Cell Lines Producing Recombinant Monoclonal Antibodies in Protein-Free Medium

There are a number of problems associated with the presence of serum in culture medium used for production, including high cost, regulatory considerations and the difficulty in removing serum proteins when pur...

Mr Adolfo J. Castillo, S. Víctores, L. Rojas… in Animal Cell Technology: From Target to Mar… (2001)

Article

Development of a pediatric liver transplantation program in Argentina

This article describes the preliminary experimental steps and clinical implementation of a purely pediatric liver transplantation (LT) program in a large public children's hospital in Buenos Aires, Argentina,...

E. Williams, H. Questa, V. Wacholder, L. Rojas… in Pediatric Surgery International (1998)

Article

Dating of mineral samples through activation analysis of argon

Mass Spectrometry has been the usual method to determine Ar concentrations in mineral samples for dating them through the⁴⁰Ar/⁴⁰K ratio. This technique has been replaced since 1966 by measurement of⁴⁰Ar/³⁹Ar rati...

M. Navarrete, L. Cabrera, F. Juarez… in Journal of Radioanalytical and Nuclear Che… (1995)