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  1. Article

    The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed Type II diabetes: the Insulin Resistance Atherosclerosis Study

    Aims/hypothesis. Proinsulin concentrations are increased relative to insulin concentrations in subjects with Type II (non-insulin-dependent) diabetes mellitus. This could be secondary to hypergly...

    L. Mykkänen, D. J. Zaccaro, C. N. Hales, A. Festa, S. M. Haffner in Diabetologia (1999)

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  2. Article

    35th Annual Meeting of the European Association for the Study of Diabetes

    A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)

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    Article

    Leptin concentrations are associated with higher proinsulin and insulin concentrations but a lower proinsulin/insulin ratio in non-diabetic subjects

    INTRODUCTION: Leptin (the product of the human OB gene) is increased in obese individuals, suggesting resistance to its effect. However, there is considerable variability in leptin levels at each level of body...

    SM Haffner, H Miettinen, L Mykkänen, MP Stern in International Journal of Obesity (1998)

  4. Article

    New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland

    Impaired glycogen synthesis after insulin stimulation accounts for most of the insulin resistance in patients with non-insulin-dependent diabetes mellitus (NIDDM). The glycogen synthase gene (GYS1), which enco...

    J. Rissanen, J. Pihlajamäki, S. Heikkinen, P. Kekäläinen, L. Mykkänen… in Diabetologia (1997)

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  5. Article

    Total immunoreactive proinsulin, immunoreactive insulin and specific insulin in relation to conversion to NIDDM: the Mexico City Diabetes Study

    Although insulin resistance and decreased insulin secretion are characteristic of established non-insulin-dependent diabetes mellitus (NIDDM), which of these metabolic abnormalities is the primary determinant...

    S. M. Haffner, C. Gonzalez, L. Mykkänen, M. Stern in Diabetologia (1997)

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    Article

    Leptin concentrations and insulin sensitivity in normoglycemic men

    OBJECTIVE: Leptin is a hormone regulating weight in the mouse. Leptin regulates food intake and appetite. Leptin concentrations are increased in obese individuals suggesting resistance to its effect. However, ...

    SM Haffner, H Miettinen, L Mykkänen, P Karhapää… in International Journal of Obesity (1997)

  7. Article

    A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects

    Recently, the presence of small dense low density lipoprotein (LDL) has been postulated to be a stronger risk factor for coronary heart disease than large LDL. While small dense LDL has been associated with in...

    Dr. S. M. Haffner, L. MykkÄnen, D. Robbins, R. Valdez, H. Miettinen… in Diabetologia (1995)

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    Article

    Is microalbuminuria part of the prediabetic state? The Mexico City Diabetes Study

    Microalbuminuria is associated with increased cardiovascular mortality in both diabetic and non-diabetic subjects. A number of studies have indicated that insulin resistance, increased blood pressure and dysli...

    Dr. S. M. Haffner, C. Gonzales, R. A. Valdez, L. Mykkänen, H. P. Hazuda… in Diabetologia (1993)

  9. Article

    Cardiovascular disease risk factors as predictors of Type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects

    Risk factors measured in a cross-sectional study in subjects aged 65–74 years living in eastern Finland were correlated with the risk of develo** diabetes 3.5 years later. Sixty-nine of 892 initially non-dia...

    L. Mykkänen, J. Kuusisto, K. Pyörälä, M. Laakso in Diabetologia (1993)

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  10. Article

    Prevalence of diabetes mellitus in elderly subjects in east Finland

    Dr. Markku Laakso, L. Mykkänen, K. Pyörälä in Diabetologia (1987)

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