-
Article
Open AccessIs glycaemic control associated with dietary patterns independent of weight change in people newly diagnosed with type 2 diabetes? Prospective analysis of the Early-ACTivity-In-Diabetes trial
It is unclear whether diet affects glycaemic control in type 2 diabetes (T2D), over and above its effects on bodyweight. We aimed to assess whether changes in dietary patterns altered glycaemic control indepen...
-
Article
Open AccessShifts in learning assistants’ self-determination due to COVID-19 disruptions in Calculus II course delivery
The Learning Assistant (LA) model with its subsequent support and training has evidenced significant gains for undergraduate STEM learning and persistence, especially in high-stakes courses like Calculus. Yet,...
-
Article
Open AccessSeasonal changes in basking shark vertical space use in the north-east Atlantic
Mobile marine species can exhibit vast movements both horizontally and vertically. Spatial analysis of vertical movements may help improve an understanding of the processes that influence space use. Previously...
-
Chapter
Quantifying Environmental Impacts of Structural Material Choices Using Life Cycle Assessment: A Case Study
The significance of environmental impact quantification for various structural materials is increasingly important for structural engineers to both understand and communicate to others. Building owners and arc...
-
Article
Open AccessLong-term satellite tracking reveals variable seasonal migration strategies of basking sharks in the north-east Atlantic
Animal migration is ubiquitous in nature with individuals within a population often exhibiting varying movement strategies. The basking shark (Cetorhinus maximus) is the world’s second largest fish species, howev...
-
Article
Vitamin C supplementation, APOE4 genotype and cognitive functioning in a rural-dwelling cohort
Apolipoprotein E4 (APOE4) genotype has been implicated as a moderating factor in cognitive function studies. Although prior studies have suggested that vitamin C is associated with better cognitive function in...
-
Article
Prospective multicenter cohort study of estrogen and insulin-like growth factor system in BRCA mutation carriers
Major clinical characteristics of BRCA1/2-related cancers include association with estrogen and metabolic consequences. We aimed to evaluate serum estradiol (E2) and insulin-like growth factor 1 (IGF-1) levels as...
-
Article
Is selective nasopharyngeal brain cooling detrimental to neuroprotection?
-
Article
Open AccessAssociations between infant feeding and the size, tempo and velocity of infant weight gain: SITAR analysis of the Gemini twin birth cohort
Infant growth trajectories, in terms of size, tempo and velocity, may programme lifelong obesity risk. Timing of breastfeeding cessation and weaning are both implicated in rapid infant growth; we examined the ...
-
Article
Open AccessConditional activation of Pik3caH1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations
Oncogenic mutations in PIK3CA, which encodes the phosphoinositide-3-kinase (PI3K) catalytic subunit p110α, occur in ∼25% of human breast cancers. In this study, we report the development of a knock-in mouse model...
-
Article
Serum cotinine and prognosis in breast cancer
Various studies have suggested that women who smoke have a worse prognosis if they develop breast cancer. Cotinine levels have been measured in sera from 511 patients with stage I and II breast cancer diagnose...
-
Article
Open AccessAdjuvant chemotherapy in older women (ACTION) study – what did we learn from the pilot phase?
The ACTION trial was initiated to provide evidence from a randomised trial on the effects of chemotherapy in women aged over 70 years where evidence for risk and benefit are lacking.
-
Article
Multiple foci of invasive breast cancer: can breast MRI influence surgical management?
The use of MRI to assess the extent of breast disease is gaining increasing popularity with the subsequent detection of multiple invasive foci within the breast that had not been identified on previous standar...
-
Article
Socioeconomic status and weight gain in early infancy
The association between low socioeconomic status (SES) and childhood obesity foreshadows lifelong inequalities in health. Insight into the causal mechanisms linking childhood adversity to long-term health coul...
-
Article
Titanium plasma spectroscopy studies under double pulse laser excitation
Laser-induced breakdown spectroscopy (LIBS) was applied for parametric studies of titanium (Ti) plasma using single and double pulsed laser excitation scheme. Here a pulsed Nd:YAG laser was employed for genera...
-
Article
A proposal to prevent severe neonatal hyperbilirubinemia and kernicterus
To address systems failures and promote a safer management of newborn jaundice, we propose an ‘aviation safety standard’ for newborn health-care services during the first week after birth. Systems failure in n...
-
Article
Synopsis report from the pilot USA Kernicterus Registry
Breakdown in systems for safe newborn health-care delivery accounts for the majority of kernicterus cases encountered in the United States. Traditional epidemiologic investigations do not track the national in...
-
Article
Kernicterus in the 21st century: frequently asked questions
Acute kernicterus remains a clinical emergency and its delayed management represents an easily preventable neonatal brain injury. Yet, practitioners encounter recurrent questions regarding the risk and timing ...
-
Article
Clinical report from the pilot USA Kernicterus Registry (1992 to 2004)
To identify antecedent clinical and health services events in infants (⩾35 weeks gestational age (GA)) who were discharged as healthy from their place of birth and subsequently sustained kernicterus. We conduc...
-
Article
The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide, with few effective therapeutic options for advanced disease. At least 40% of HCCs are clonal, potentially arising from STAT...
