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  1. Article

    Open Access

    Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation

    Stress is a major risk factor for the development of mood and anxiety disorders; elucidation of novel approaches to mitigate the deleterious effects of stress could have broad clinical applications. Pharmacolo...

    R J Bluett, J C Gamble-George, D J Hermanson, N D Hartley… in Translational Psychiatry (2014)

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  2. Article

    Correction: Corrigendum: Aberrant cannabinoid signaling impairs oviductal transport of embryos

    Nat. Med. 10, 1074–1080 (2004). In the online version of this article, the right axis of the graph in Figure 1a was missing its label. It should be labeled 'average litter size.' Also in the online version, th...

    H Wang, Y Guo, D Wang, P J Kingsley, L J Marnett, S K Das, R N DuBois… in Nature Medicine (2004)

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  3. No Access

    Chapter and Conference Paper

    Structure, Function and Inhibition of Cyclo-oxygenases

    The key step in the generation of prostaglandins (PGs) is the bis-dioxygenation of arachidonic acid to the bicyclic hydroperoxides PGG2 (endoperoxides) as the initial products of polyunsaturated fatty-acid oxygen...

    L. J. Marnett in Advances in Eicosanoid Research (2000)

  4. No Access

    Chapter

    Oxidant Generation in Mouse Skin in Response to Phorbol Ester Tumor Promoters

    Oxygen radicals are believed to play an important role in cellular pathologies such as reperfusion injury, xenobiotic-induced toxicity, and chemically-induced cancer. Strong circumstantial evidence suggests ge...

    L. J. Marnett, C. Ji in Eicosanoids and Other Bioactive Lipids in … (1993)

  5. No Access

    Chapter

    Transformation of Exogenous Arachidonic Acid into a New Metabolite, 12-Keto- 5,8,10,14-Eicosatetraenoic Acid by Lewis Lung Carcinoma Cells: Implications in Tumor Cell Metastasis

    Tumor cell arrest is a critical event in successful tumor cell metastasis. Arachidonic acid (AA) metabolites are believed to play a crucial role in this phase of the metastatic cascade. The lipoxygenase metabo...

    Z. M. Duniec, L. J. Marnett, K. V. Honn in Eicosanoids and Other Bioactive Lipids in … (1993)

  6. No Access

    Chapter

    ESR Investigation of Tyrosyl Radicals of Prostaglandin H Synthase; Relation to Enzyme Catalysis

    Prostaglandin H Synthase (PHS) catalyses the oxygenation of arachidonic acid to prostaglandin endoperoxides, the initial step in prostaglandin, thromboxane, and prostacyclin biosynthesis. PHS exhihits two cata...

    G. Lassmann, R. Odenwaller, J. F. Curtis… in Eicosanoids and Other Bioactive Lipids in … (1993)

  7. No Access

    Chapter

    Stimulation and Inhibition of Oxygen Radical Formation by Ascorbic Acid and 13-CIS-Retinoic Acid

    Oxygen radicals are implicated in various stages of carcinogenesis and radical scavengers inhibit tumorigenesis in some models (1–4). However, many presumed radical scavengers exhibit radical generating activi...

    L. J. Marnett, V. Samokyszyn, D. Laudicina in Eicosanoids and Other Bioactive Lipids in … (1991)