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Article
Open AccessTopical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72)
Migraine is a debilitating neurological disorder where trigeminovascular activation plays a key role. We have previously reported that local application of Complete Freund’s Adjuvant (CFA) onto the dura mater ...
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Article
Open AccessKYNA analogue SZR72 modifies CFA-induced dural inflammation- regarding expression of pERK1/2 and IL-1β in the rat trigeminal ganglion
Neurogenic inflammation has for decades been considered an important part of migraine pathophysiology. In the present study, we asked the question if administration of a novel kynurenic acid analogue (SZR72), ...
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Article
Open AccessKynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion
The trigeminal ganglion (TG) plays a central role in cranial pain. Administration of complete Freund’s adjuvant (CFA) into the temporomandibular joint (TMJ) elicits activation of TG. Kynurenic acid (KYNA) is a...
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Article
Open AccessDural administration of inflammatory soup or Complete Freund’s Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion
Migraine is a painful disorder with a huge impact on individual and public health. We hypothesize that migraine pain originates from a central mechanism that results secondarily in hypersensitivity in peripher...
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Article
Open AccessCGRP and CGRP receptors in human and rhesus monkey cerebellum
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Article
Open AccessDifferentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system
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Article
Open AccessP10.01 Involvement of Calcium-Calmodulin Dependent Protein Kinase II on Endothelin Receptor Expression in Cerebral Arteries Of Rat
Experimental cerebral ischemia and organ culture of cerebral arteries result in enhanced expression of endothelin ETB receptors in smooth muscle cells. The present study was designed to evaluate the involvement o...
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Article
Increased ETA and ETB receptor contraction in the left internal mammary artery from patients with hypertension
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Chapter and Conference Paper
Elevated intracranial pressure or subarachnoid blood responsible for reduction in cerebral blood flow after SAH
The pathogenesis of cerebral ischemia after subarachnoid hemorrhage (SAH) still remains elusive. The purpose of the present study was to examine whether it is the change in intracranial pressure (ICP) or the e...
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Chapter and Conference Paper
Subarachnoid hemorrhage induces upregulation of vascular receptors and reduction in rCBF via an ERK1/2 mechanism
Previous studies have shown that endothelin type B (ETB) and 5-hydroxytryptamine type 1B (5-HT1B) receptors are upregulated following subarachnoid hemorrhage (SAH). The purpose of the present study was to test wh...
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Article
Protection against myocardial ischaemia/reperfusion injury by PPAR–α activation is related to production of nitric oxide and endothelin–1
Ligands of peroxisome proliferator–activated receptor alpha (PPAR–α) have been shown to reduce ischaemia/reperfusion injury. The mechanisms behind this effect are not well known. We hypothesized that activatio...
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Article
Enhanced vasodilator responses to calcitonin gene-related peptide (CGRP) in subcutaneous arteries in human hypertension
Isolated segments (1–2 mm) of small subcutaneous arteries (diameter 0.1–0.9 mm) and veins (0.1–1.0 mm) from patients with hypertension (essential n = 13, renovascular n = 6) and controls (n = 17) were examined. T...
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Chapter and Conference Paper
Influence of Brain Natriuretic Peptide on Phenotypic Change of Cerebral Vasculature
Brain Natriuretic Peptide (BNP) belongs to the family of natriuretic peptides, the other members being Atrial Natriuretic Peptide (ANP) and C-type Natriuretic Peptide (CNP); each type also existing in iso-form...
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Article
Blockade of nitric oxide decreases the renal vasodilatory effect of neuropeptide Y in the insulin-treated diabetic rat
The effect of 50 days of streptozotocine-induced diabetes mellitus (blood glucose 20 mmol/l) on contraction and relaxation of isolated renal and intrarenal arteries in rats were examined. Strong and similar c...
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Article
Mechanical properties and effects of sympathetic co-transmitters on human coronary arteries and veins
Active isometric wall tension was studied at different levels of passive wall tension in isolated circular 2 mm long segments of human epicardial coronary arteries and veins, and maximum active wall tension wa...
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Article
Alterations in perivascular dilatory neuropeptides (CGRP, SP, VIP) in the external jugular vein and in the cerebrospinal fluid following subarachnoid haemorrhage in man
A possible involvement of perivascular vasodilatory neuropeptides in subarachnoid haemorrhage (SAH) has been evaluated in man by measuring the levels of calcitonin gene related peptide (CGRP)-, substance P (SP...
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Article
Sympathetic activation after two weeks of nifedipine treatment in primary Raynaud's patients and controls
The effect of a standardized cold pressor test on circulating noradrenaline and neuropeptide-Y-like immunoreactivity was investigated in 12 women with primary Raynaud's phenomenon and 12 healthy female control...
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Article
Yohimbine pharmacokinetics and interaction with the sympathetic nervous system in normal volunteers
The pharmacokinetics of yohimbine and its effects on sympathoadrenal function were studied in 13 young, healthy, male volunteers after an IV bolus dose of 0.25 or 0.5 mg · kg−1.
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Article
Comparison of the calcium entry blockers nimodipine and flunarizine on human cerebral and temporal arteries: role in cerebrovascular disorders
The effect of the calcium entry blockers flunarizine and nimodipine on isolated human cerebral and temporal arteries has been studied.
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Article
Changes in the levels of neuropeptide Y-LI in the external jugular vein in connection with vasoconstriction following subarachnoid haemorrhage in man
NPY is a putative neurotransmitter mainly co-localized with noradrenaline in sympathetic fibers which innervate the cerebral vasculature. The origin of most of the perivascular NPY fibers seems to be in the su...
