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Article
Late Pleistocene marine coastal deposits of Formentera Island and S’Espalmador islet (Balearic archipelago, western Mediterranean): climatic and geomorphological evolution
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Article
Open AccessA role for MALT1 activity in Kaposi’s sarcoma-associated herpes virus latency and growth of primary effusion lymphoma
Primary effusion lymphoma (PEL) is an incurable malignancy that develops in immunodeficient patients as a consequence of latent infection of B-cells with Kaposi’s sarcoma-associated herpes virus (KSHV). Malign...
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Article
Open AccessRetinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype
Neuroendocrine tumors (NETs), which can have survival rates as low as 4%, currently have limited therapeutic interventions available highlighting the dire need for the identification of novel biological target...
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Article
Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia
New treatments for adults with acute lymphoblastic T-cell leukemia (T-ALL) are urgently needed, as the current rate of overall remission in these patients is only about 40 percent. We recently showed the poten...
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Article
IGF-IR-dependent expression of Survivin is required for T-antigen-mediated protection from apoptosis and proliferation of neural progenitors
The insulin-like growth factor-1 receptor (IGF-IR) and the human polyomavirus JCV protein, T-antigen cooperate in the transformation of neuronal precursors in the cerebellum, which may be a contributing factor...
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Article
Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin
The human immunodeficiency virus type 1 (HIV-1) viral protein R (vpr) gene is an evolutionarily conserved gene among the primate lentiviruses. Several functions are attributed to Vpr including the ability to caus...
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Article
Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines
We have previously reported that insulin-like growth factor-I (IGF-I) supports growth and survival of mouse and human medulloblastoma cell lines, and that IGF-I receptor (IGF-IR) is constitutively phosphorylat...
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Article
p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
HIV-1 Tat is a potent transcriptional activator of the viral promoter with the ability to modulate a number of cellular regulatory circuits including apoptosis. Tat exerts its effects through interaction with ...
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Article
Poster display I clinical general
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Chapter and Conference Paper
A Comparative Analysis of the Effect of Glucagon and Atropine in the Sinus and Atrio Ventricular Nodes
The drug management of sick sinus syndrome (SSS.) at the present time is not optimal. Due to this we decided to investigate the effect of Atropine (A) and Glucagon (G) in this syndrome. The effect of Glucagon ...