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Article
Circulating immune complexes as markers of response to chemotherapy in malignant teratomas and gestational trophoblastic tumours
Concentrations of circulating immune complexes (CIC) were measured serially during chemotherapy of 22 patients with gestational trophoblastic tumours (GTT) and 11 patients with malignant teratoma (MT) by the p...
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Article
Identification of PEG-precipitable serum factor associated with malignant lymphoma as C-reactive protein
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Chapter
Basal Forebrain Cholinergic Systems in Primate Brain: Anatomical Organization and Role in the Pathology of Aging and Dementia
Over the past several years, there have been substantial advances in our understanding of cholinergic systems in the primate central nervous system. Cholinergic neurons in the medial septum, diagonal band of B...
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Article
Cellular/molecular biological studies of brain abnormalities in Alzheimer's disease and animal models
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Chapter
Brain abnormalities in aged monkeys: a model sharing features with Alzheimer’s disease
Macaques develop age-associated cognitive/memory impairments as well as brain abnormalities (particularly senile plaques) similar to those occurring in the brains of older humans and individuals with Alzheimer...
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Article
Amyloid in the brains of aged squirrel monkeys
In this immunocytochemical study, the brains of nine squirrel monkeys (Saimiri sciureus), ranging from 8 to 27 years of age, were examined for the presence and distribution of β/A4 amyloid, a 4-kilodalton peptide...
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Chapter and Conference Paper
Amyloid in Alzheimer’s Disease and Animal Models
Animal models provide unique opportunities to analyze mechanisms of βamyloid protein (Aβ) amyloidogenesis. One set of studies in control animals was designed to identify the neural cells that express the amyloid ...
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Article
Apolipoprotein E4 promotes the early deposition of Aβ42 and then Aβ40 in the elderly
The apolipoprotein Eɛ4 allele (ApoEɛ4) is associated with a selective increase in deposition of the 40-amino acid form of the β-amyloid peptide (Aβ40) in end-stage Alzheimer’s disease. To determine how apoE g...
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Article
Modeling Alzheimer's disease and other proteopathies in vivo: Is seeding the key?
Protein misfolding and aberrant polymerization are salient features of virtually all central neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, triplet repeat disorders, tau...
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Article
Open Access16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010
This chapter summarises the results of the preceding sections, which estimate the fraction of cancers occurring in the UK in 2010 that can be attributed to sub-optimal, past exposures of 14 lifestyle and envir...
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Article
Patient age of less than 55 years is not an independent predictor of functional improvement or satisfaction after total knee arthroplasty
Management of the young patient with end-stage osteoarthritis of the knee is difficult, with surgical options of osteotomy, partial or total knee arthroplasty (TKA). The primary aim of this study was to assess...
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Article
Breast cancer and cytomegalovirus
To determine whether cytomegalovirus is causally associated with breast cancer and whether cytomegalovirus should be categorised as an oncogenic virus.