12 Result(s)

Article

Breast cancer and cytomegalovirus

To determine whether cytomegalovirus is causally associated with breast cancer and whether cytomegalovirus should be categorised as an oncogenic virus.

A. K. Richardson, L. C. Walker, B. Cox, H. Rollag… in Clinical and Translational Oncology (2020)

Article

Patient age of less than 55 years is not an independent predictor of functional improvement or satisfaction after total knee arthroplasty

Management of the young patient with end-stage osteoarthritis of the knee is difficult, with surgical options of osteotomy, partial or total knee arthroplasty (TKA). The primary aim of this study was to assess...

N. D. Clement, L. C. Walker, M. Bardgett… in Archives of Orthopaedic and Trauma Surgery (2018)

Article

Modeling Alzheimer's disease and other proteopathies in vivo: Is seeding the key?

 Protein misfolding and aberrant polymerization are salient features of virtually all central neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, triplet repeat disorders, tau...

L. C. Walker, F. Bian, M. J. Callahan, W. J. Lipinski, R. A. Durham… in Amino Acids (2002)

Article

Apolipoprotein E4 promotes the early deposition of Aβ42 and then Aβ40 in the elderly

The apolipoprotein Eɛ4 allele (ApoEɛ4) is associated with a selective increase in deposition of the 40-amino acid form of the β-amyloid peptide (Aβ40) in end-stage Alzheimer’s disease. To determine how apoE g...

L. C. Walker, J. Pahnke, M. Madauss, S. Vogelgesang, A. Pahnke… in Acta Neuropathologica (2000)

Chapter and Conference Paper

Amyloid in Alzheimer’s Disease and Animal Models

Animal models provide unique opportunities to analyze mechanisms of βamyloid protein (Aβ) amyloidogenesis. One set of studies in control animals was designed to identify the neural cells that express the amyloid ...

D. L. Price, B. T. Lamb, J. D. Gearhart… in Amyloid Protein Precursor in Development, … (1994)

Article

Amyloid in the brains of aged squirrel monkeys

In this immunocytochemical study, the brains of nine squirrel monkeys (Saimiri sciureus), ranging from 8 to 27 years of age, were examined for the presence and distribution of β/A4 amyloid, a 4-kilodalton peptide...

L. C. Walker, C. Masters, K. Beyreuther, D. L. Price in Acta Neuropathologica (1990)

Chapter

Brain abnormalities in aged monkeys: a model sharing features with Alzheimer’s disease

Macaques develop age-associated cognitive/memory impairments as well as brain abnormalities (particularly senile plaques) similar to those occurring in the brains of older humans and individuals with Alzheimer...

D. L. Price M. D., E. H. Koo, S. S. Sisodia… in Alzheimer’s Disease. Epidemiology, Neuropa… (1990)

Article

Cellular/molecular biological studies of brain abnormalities in Alzheimer's disease and animal models

D. L. Price, E. H. Koo, S. S. Sisodia… in Journal of Neural Transmission - Parkinson… (1989)

Chapter

Basal Forebrain Cholinergic Systems in Primate Brain: Anatomical Organization and Role in the Pathology of Aging and Dementia

Over the past several years, there have been substantial advances in our understanding of cholinergic systems in the primate central nervous system. Cholinergic neurons in the medial septum, diagonal band of B...

D. L. Price, C. A. Kitt, J. C. Hedreen… in Dynamics of Cholinergic Function (1986)

Article

Identification of PEG-precipitable serum factor associated with malignant lymphoma as C-reactive protein

L C Walker, D F Tucker, R H Begent in British Journal of Cancer (1983)

Article

Circulating immune complexes as markers of response to chemotherapy in malignant teratomas and gestational trophoblastic tumours

Concentrations of circulating immune complexes (CIC) were measured serially during chemotherapy of 22 patients with gestational trophoblastic tumours (GTT) and 11 patients with malignant teratoma (MT) by the p...

R H Begent, K A Chester, L C Walker, D F Tucker in British Journal of Cancer (1982)