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Article
Development and validation of stability indicating high-performance liquid chromatographic assays for ketotifen in aqueous and silicon oil formulations
A simple and specific high-performance liquid chromatographic (HPLC) method for the analysis of ketotifen in aqueous solutions and silicon oil suspensions is described. The HPLC system is based on a reversed p...
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Article
High performance liquid chromatographic analysis of theIn vitro N-dealkylated andN-oxide metabolites ofN-ethyl-N-methylaniline: Methodology for the determination of enzyme activity and stereoselectivity ofN-oxidation
A robust, sensitive reverse-phase high-performance liquid chromatographic (HPLC) method for the quantification of the majorin vitro oxidative microsomal metabolites of the prochiral tertiary amineN-ethyl-N-methyl...
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Article
Enantiomeric resolution ofN-alkyl-N-methylanilineN-oxides by high-performance liquid chromatography
A high-performance liquid chromatographic method for the resolution of the enantiomers of a series ofN-alkyl-N-methylanilineN-oxides is reported. The resolutions were achieved using a Chiralcel, OD chiral station...