11 Result(s)

Article

The effects of a synthetic diet on the pharmacokinetics of ethyl methyl sulphide and its sulphoxide and sulphone metabolites in rats

Ethyl methyl sulphide (EMS) is a simple dialkyl sulphide, which occurs naturally and forms part structures of more complex drug molecules. EMS is oxidized to the corresponding sulphoxide (EMSO) and sulphone (E...

I. P. Nnane, L. A. Damani, A. J. Hutt in European Journal of Drug Metabolism and Ph… (2001)

Article

Pharmacokinetics of 2-methoxyphenylmetyrapone and 2-bromophenylmetyrapone in rats

The pharmacokinetics of two 2-substituted phenylmetyrapone analogues, 2-methoxyphenylmetyrapone (2-MPMP) and 2-bromophenylmetyrapone (2-BrPMP), developed as potential adrenal imaging agents, were investigated ...

I. P. Nnane, M-C. Tsai, G. Lin, L. A. Damani… in European Journal of Drug Metabolism and Ph… (1999)

Chapter and Conference Paper

The Effect of Metabolic Degradation on Radiotracer Design

Metyrapone, a potent inhibitor of llβ-hydroxylation in the adrenal cortex has been chemically modified to facilitate labelling with SPECT and PET radionuclides. The 2substituted phenylmetyrapone derivatives 2-...

I. Zolle, Ch. Halldin, C.-G. Swahn… in Radioactive Isotopes in Clinical Medicine … (1999)

Article

Development and validation of stability indicating high-performance liquid chromatographic assays for ketotifen in aqueous and silicon oil formulations

A simple and specific high-performance liquid chromatographic (HPLC) method for the analysis of ketotifen in aqueous solutions and silicon oil suspensions is described. The HPLC system is based on a reversed p...

I. P. Nnane, L. A. Damani, A. J. Hutt in Chromatographia (1998)

Article

High performance liquid chromatographic analysis of theIn vitro N-dealkylated andN-oxide metabolites ofN-ethyl-N-methylaniline: Methodology for the determination of enzyme activity and stereoselectivity ofN-oxidation

A robust, sensitive reverse-phase high-performance liquid chromatographic (HPLC) method for the quantification of the majorin vitro oxidative microsomal metabolites of the prochiral tertiary amineN-ethyl-N-methyl...

M. R. Hadley, H. G. Oldham, L. A. Damani, A. J. Hutt in Chromatographia (1998)

Article

Triazolines 34. Structure and Stability Relationships of Novel Δ²-l,2,3-Triazoline Anticonvulsants

Albert H. L. Chow, Francis C. K. Chiu, L. A. Damani… in Pharmaceutical Research (1996)

Article

Enantiomeric resolution ofN-alkyl-N-methylanilineN-oxides by high-performance liquid chromatography

A high-performance liquid chromatographic method for the resolution of the enantiomers of a series ofN-alkyl-N-methylanilineN-oxides is reported. The resolutions were achieved using a Chiralcel, OD chiral station...

M. R. Hadley, L. A. Damani, A. J. Hutt, H. G. Oldham, J. Murphy… in Chromatographia (1993)

Chapter

Reduction and conjugation reactions of N-oxides

In the biological oxidation of nitrogen functionalities in xenobiotics, two processes are discernible — those where there is removal of electrons and protons, and those where there is addition of oxygen. This cha...

L. A. Damani in N-Oxidation of Drugs (1991)

Article

The metabolic N-oxidation of 3-substituted pyridines in various animal species in vivo

The intraperitoneal administration of pyridine, 3-methylpyridine and 3-chloropyridine to mice, hamsters, rats, guinea-pigs, rabbits and ferrets, resulted in the urinary excretion of their N-oxides. Pyridine-N-...

J. W. Gorrod, L. A. Damani in European Journal of Drug Metabolism and Pharmacokinetics (1980)

Chapter

Evidence for Two Distinct Tertiary Amine Oxidases

J. W. Gorrod, L. A. Damani, L. Patterson in Deutsche Pharmakologische Gesellschaft (1978)