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Article
Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood
Permanent alopecia after haematopoietic stem cell transplantation (HSCT) is distressing and few studies have investigated this late effect. The aim of the study was to assess the percentage of patients with al...
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Article
Development of clinical practice guidelines for supportive care in childhood cancer—prioritization of topics using a Delphi approach
Currently, very few guidelines for supportive care for children with cancer exist. In the Netherlands, nationwide guidelines are over 10 years old and mostly based on expert opinion. Consequently, there is gro...
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Article
Immediate and long-term somatic effects, and health-related quality of life of BM donation during early childhood. A single-center report in 210 pediatric donors
Since 1968, when Leiden undertook the first successful European pediatric BM transplantation with a 7-year-old sibling donor, more than 300 young children have donated BM in our unit. We first retrospectively ...
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Article
Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation
When compared with BMT, umbilical cord blood transplantation (UCBT) is associated with a lower rate of engraftment and delayed hematological/immunological recovery. This leads to increased risk of TRM in the e...
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Article
High burden of late effects after haematopoietic stem cell transplantation in childhood: a single-centre study
The aim of our study was to assess the cumulative incidence and severity (‘burden’) of late effects in a single-centre cohort of childhood haematopoietic stem cell transplantation (HSCT) survivors, at least 2 ...
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Article
Secundaire hemofagocytaire lymfohistiocytose bij kinderen met een hematologische maligniteit
Hemofagocytaire lymfohistiocytose (HLH) is een zeldzaam ziektebeeld dat onder andere kan ontstaan bij kinderen die zijn gediagnosticeerd met een maligniteit. In dit artikel worden drie casus besproken van pati...
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Article
Potential role of mesenchymal stromal cells in pediatric hematopoietic SCT
Mesenchymal stromal cells (MSCs) can be isolated from several human tissues and expanded for clinical use. MSCs are identified by phenotypic and functional characteristics, and are poor Ag-presenting cells not...
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Article
Acute GvHD: pathogenesis and classification
Allogeneic hematopoietic SCT (HSCT) is an established treatment for some children with life-threatening hematological disease, immune deficiencies and inborn errors of metabolism. Despite advances in preventio...
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Article
Response to the letter by M Koyama et al
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Article
Allogeneic bone marrow transplantation for juvenile myelomonocytic leukemia: a single center experience of 23 patients
Juvenile myelomonocytic leukemia (JMML) is a childhood leukemia for which allogeneic BMT is the only curative therapy. At our pediatric stem cell transplantation unit, we performed 26 BMTs in 23 children (age ...
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Article
Graft dysfunction and delayed immune reconstitution following haploidentical peripheral blood hematopoietic stem cell transplantation
For many children with life-threatening hematological diseases, hematopoietic stem cell transplantation (HSCT) is the only curative option. In children lacking a matched related or unrelated donor and with the...
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Article
Intravenous busulfan in children prior to stem cell transplantation: study of pharmacokinetics in association with early clinical outcome and toxicity
We studied the pharmacokinetics of intravenous busulfan (Bu) in children in order to further optimize intravenous Bu dosing in relation to toxicity and survival. A total of 31 children undergoing Bu-based cond...
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Article
Paediatric allogeneic bone marrow transplantation for homozygous β-thalassaemia, the Dutch experience
We reviewed the results of the Dutch paediatric bone marrow transplant (BMT) program for children receiving HLA-identical BMT for β-thalassaemia major over an 18-year period. In all, 19 patients underwent a total...
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Chapter
S9-Dependent Activation of 1-Nitropyrene and 3-Nitrofluoranthene in Bacterial Mutagenicity Assays
Nitro-substituted polycyclic aromatic hydrocarbons (NO2PAH) such as 1-nitropyrene (NP) and 3-nitrofluoranthene (NFA; see Fig. 1) have been detected in diesel and other combustion emissions (Nishioka et al., 1982;...