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  1. Article

    Open Access

    Epigenomics alternations and dynamic transcriptional changes in responses to 5-fluorouracil stimulation reveal mechanisms of acquired drug resistance of colorectal cancer cells

    A drug-induced resistant cancer cell is different from its parent cell in transcriptional response to drug treatment. The distinct transcriptional response pattern of a drug-induced resistant cancer cell to dr...

    Y Shen, M Tong, Q Liang, Y Guo, H Q Sun, W Zheng, L Ao… in The Pharmacogenomics Journal (2018)

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  2. Article

    Open Access

    Multi-omics landscapes of colorectal cancer subtypes discriminated by an individualized prognostic signature for 5-fluorouracil-based chemotherapy

    Until recently, few prognostic signatures for colorectal cancer (CRC) patients receiving 5-fluorouracil (5-FU)-based chemotherapy could be used in clinical practice. Here, using transcriptional profiles for a ...

    M Tong, W Zheng, H Li, X Li, L Ao, Y Shen, Q Liang, J Li, G Hong, H Yan… in Oncogenesis (2016)

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  3. Article

    Open Access

    SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer

    Although members of SOX family have been well documented for their essential roles in embryonic development, cell proliferation and disease, the functional role and molecular mechanism of SOX30 in cancer are l...

    F Han, W Liu, X Jiang, X Shi, L Yin, L Ao, Z Cui, Y Li, C Huang, J Cao, J Liu in Oncogene (2015)

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  4. Article

    Open Access

    Similar blood-borne DNA methylation alterations in cancer and inflammatory diseases determined by subpopulation shifts in peripheral leukocytes

    Although many DNA methylation (DNAm) alterations observed in peripheral whole blood/leukocytes and serum have been considered as potential diagnostic markers for cancer, their origin and their specificity for ...

    H Li, T Zheng, B Chen, G Hong, W Zhang, T Shi, S Li, L Ao… in British Journal of Cancer (2014)

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  5. No Access

    Article

    Precipitates of Cr at Σ3 <110> {112} GB in α-Fe

    Precipitates of Cr at Σ3 <110> {112} GB in α-Fe have been studied using molecular dynamics with a two-band embedded atomic model potential. The accumulation and segregation of Cr atoms and the evolution of the...

    Y. Y. Dai, L. Ao, Q. Q. Sun, L. Yang, J. L. Nie… in MRS Online Proceedings Library (2014)