-
Article
The inhibitory effect of dibutyryl cyclic AMP on docosahexaenoic acid-induced apoptosis in HL-60 cells through activation of the phosphatidylinositol-3 kinase pathway
Docosahexaenoic acid (DHA) is known as a chemopreventive substance for cancers. Previously we reported that DHA induces apoptosis in HL-60 cells. The aim of this study was to clarify the role of phosphatidylin...
-
Article
Suppressive effects of ascorbate derivatives on ultraviolet-B-induced injury in hacat human keratinocytes
The aging of skin, including sunburning, is caused by ultraviolet (UV) irradiation. Here, we examined the inhibitory effect of ascorbic acid (AsA) and its derivatives AsA 2-phosphate (AA-2P) and AsA 2-glucosid...
-
Article
Protection from chemotherapy-induced alopecia by docosahexaenoic acid
-
Article
In vitro neurotoxicity of amyloid β-peptide cross-linked by transglutaminase
Transglutaminase catalyzes the intermolecular cross-linking of peptides between Gln and Lys residues, forming an ε-(γ-glutamyl) lysine bond. Amyloid β-peptide, a major constituent of the deposits in Alzheimer ...
-
Article
Effect of forskolin on platelet deaggregation and cyclic AMP generation
The diterpene, forskolin, induced a partial deaggregation of ADP-or collagen-aggregated human platelets in vitro. An increase in platelet cyclic AMP by forskolin was assumed to mediate the platelet deaggregati...
