6 Result(s)
within
Kyoung Min Kim
Biomedicine
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Article
Open AccessClinical significance of p53 protein expression and TP53 variation status in colorectal cancer
In human colorectal cancer (CRC), TP53 is one of the most important driver genes. Immunohistochemistry (IHC) has been used most often to assess the variational status of TP53. Recently, next-generation sequencing...
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Article
Open AccessInhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma
SIRT6 has diverse roles in cells, and the role of SIRT6 in tumorigenesis is controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might be involved in resistance to anti-cancer th...
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Article
Open AccessFAM83H is involved in stabilization of β-catenin and progression of osteosarcomas
FAM83H was initially identified as a protein essential for dental enamel formation. Recent reports have shown that FAM83H is also involved in the progression of human cancers in conjunction with tumor-associat...
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Article
Open AccessExpression of oxidized protein tyrosine phosphatase and γH2AX predicts poor survival of gastric carcinoma patients
Oxidative stress induces various intracellular damage, which might be correlated with tumorigenesis. Accumulated oxidative stresses might inactivate protein tyrosine phosphatase (PTP) by oxidizing it, and indu...
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Article
Open AccessThe PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma
PARP1 facilitates the recovery of DNA-damaged cells by recruiting DNA damage response molecules such as γH2AX and BRCA1/2, and plays a role in resistance to antitumor therapies. Therefore, PARP inhibition bein...
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Article
Colloidal behaviors of ZnO nanoparticles in various aqueous media
We have evaluated the particle sizes, zeta potentials and hydrodynamic radii of zinc oxide (ZnO) nanoparticles in various aqueous conditions such as deionized water, phosphate buffered saline and Minimum Essen...
