-
Article
Open AccessPast, present, and future of cell replacement therapy for parkinson’s disease: a novel emphasis on host immune responses
Parkinson’s disease (PD) stands as the second most common neurodegenerative disorder after Alzheimer’s disease, and its prevalence continues to rise with the aging global population. Central to the pathophysio...
-
Article
Open AccessUltrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas
Given the marginal penetration of most drugs across the blood-brain barrier, the efficacy of various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed ultrasound (LIPU) and int...
-
Article
Open AccessAn optimized Nurr1 agonist provides disease-modifying effects in Parkinson’s disease models
The nuclear receptor, Nurr1, is critical for both the development and maintenance of midbrain dopamine neurons, representing a promising molecular target for Parkinson’s disease (PD). We previously identified ...
-
Article
Co-transplantation of autologous Treg cells in a cell therapy for Parkinson’s disease
The specific loss of midbrain dopamine neurons (mDANs) causes major motor dysfunction in Parkinson’s disease, which makes cell replacement a promising therapeutic approach1–4. However, poor survival of grafted mD...
-
Article
Open AccessCheckpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade
Whereas the contribution of tumor microenvironment to the profound immune suppression of glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that regulate resistance to CD8 T cell mediated killing are...
-
Article
Open AccessNovel application of sodium manganese oxide in removing acidic gases in ambient conditions
In this study, we have demonstrated the application of sodium manganese oxide for the chemisorption of toxic acidic gases at room temperature. The fabricated alkali ceramic has Na0.4MnO2, Na2Mn3O7, and NaxMnO2 ph...
-
Article
Open AccessEnhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer
Ferroptosis provides an opportunity to overcome the cancer cell therapeutic resistance and modulate the immune system. Here an interaction between ferroptosis of cancer cells and natural killer (NK) cells was ...
-
Article
Open AccessProbing the origin and stability of bivalency in copper based porous coordination network and its application for H2S gas capture
A bivalent Cu(I,II) metal–organic framework (MOF) based on the 4,4′,4″-s-Triazine-2,4,6-triyl-tribenzoate linker was synthesized via a solvothermal method. The MOF possessed 43.8% of the Cu sites as Cu+ with a su...
-
Article
Open AccessTernary metal oxide nanocomposite for room temperature H2S and SO2 gas removal in wet conditions
A ternary Mn–Zn–Fe oxide nanocomposite was fabricated by a one-step coprecipitation method for the remotion of H2S and SO2 gases at room temperature. The nanocomposite has ZnO, MnO2, and ferrites with a surface a...
-
Article
Spotting-based differentiation of functional dopaminergic progenitors from human pluripotent stem cells
To fully realize the potential of human pluripotent stem cells (hPSCs) for both therapeutic and research purposes, it is critical to follow an efficient and reliable in vitro differentiation method that is bas...
-
Article
Open AccessIdentification of disease-linked hyperactivating mutations in UBE3A through large-scale functional variant analysis
The mechanisms that underlie the extensive phenotypic diversity in genetic disorders are poorly understood. Here, we develop a large-scale assay to characterize the functional valence (gain or loss-of-function...
-
Article
Open AccessMetal organic framework derived NaCoxOy for room temperature hydrogen sulfide removal
Novel NaCoxOy adsorbents were fabricated by air calcination of (Na,Co)-organic frameworks at 700 °C. The NaCoxOy crystallized as hexagonal microsheets of 100–200 nm thickness with the presence of some polyhedral ...
-
Article
Transition metal-based metal–organic frameworks for environmental applications: a review
Rapid industrialization is deteriorating air and water quality by exposing life to a wide range of pollutants, thus calling for efficient and affordable remediation strategies. Metal–organic frameworks (MOFs) ...
-
Chapter and Conference Paper
Full Scale Computations for Resistance and Self-propulsion Performances of Commercial Ship by RANS Simulations
This paper shows the feasibility study on the numerical prediction for the performances of resistance and self-propulsion characteristics for a full scale ship by using the RANS (Reynolds-Averaged Navier-Stok...
-
Article
Open AccessPotent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
Until recently, Nurr1 (NR4A2) was known as an orphan nuclear receptor without a canonical ligand-binding domain, featuring instead a narrow and tight cavity for small molecular ligands to bind. In-depth charac...
-
Article
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
The orphan nuclear receptor Nurr1 is critical for the development, maintenance and protection of midbrain dopaminergic (mDA) neurons. Here we show that prostaglandin E1 (PGE1) and its dehydrated metabolite, PG...
-
Article
Preparation of Fe-Co-ZSM-5 Bimetal Catalysts with Different Alternate Metal Inclusions for Catalytic Removal of VOCs from Air
The catalytic oxidation of volatile organic compounds (VOCs) has been studied in a series of bimetal (Fe-Co)-incorporated ZSM-5 zeolites. The bimetal incorporation was varied. The first sample was prepared by ...
-
Article
Open AccessPhotocatalytic Degradation of Organic Pollutants over MFe2O4 (M = Co, Ni, Cu, Zn) Nanoparticles at Neutral pH
In this study, we report a surfactant-mediated synthesis of ferrites (MFe2O4: M = Co, Ni, Cu, Zn) using the co-precipitation-oxidation method. The band gap calculated from UV-Visible diffuse reflectance spectra w...
-
Article
Open AccessA surrogate weighted mean ensemble method to reduce the uncertainty at a regional scale for the calculation of potential evapotranspiration
We propose a weighted ensemble approach using a surrogate variable. As a case study, the degree of agreement (DOA) statistics for potential evapotranspiration (PET) was determined to compare the ordinary arith...
-
Article
Open AccessMaternal and early postnatal immune activation produce sex-specific effects on autism-like behaviors and neuroimmune function in mice
Increasing evidence suggests a role for inflammation in neuropsychiatric conditions including autism spectrum disorder (ASD), a neurodevelopmental syndrome with higher prevalence in males than females. Here we...
