Skip to main content

5 Result(s)

within Kwang-Hyun Park Remove this filter Cell Biology Remove this filter

and

  1. No Access

    Article

    Highly efficient and specific regulation of gene expression using enhanced CRISPR-Cas12f system

    The recently developed CRISPR activator (CRISPRa) system uses a CRISPR-Cas effector-based transcriptional activator to effectively control the expression of target genes without causing DNA damage. However, ex...

    Yeounsun Oh, Lee Wha Gwon, Hyomin K. Lee, Junho K. Hur, Kwang-Hyun Park… in Gene Therapy (2024)

  2. Article

    Author Correction: Hypercompact adenine base editors based on a Cas12f variant guided by engineered RNA

    Do Yon Kim, Yuhee Chung, Yu** Lee, Dongmin Jeong… in Nature Chemical Biology (2023)

    Download PDF (745 KB) View Article

  3. No Access

    Article

    Hypercompact adenine base editors based on a Cas12f variant guided by engineered RNA

    Cas12f is a hypercompact type V, Cas12 family member. Previously, we reported a set of engineered guide RNAs supporting high indel efficiency for Cas12f1 in human cells. Here we suggest a new technology whereb...

    Do Yon Kim, Yuhee Chung, Yu** Lee, Dongmin Jeong… in Nature Chemical Biology (2022)

  4. No Access

    Article

    Methyl β-cyclodextrin activates eNOS-cGMP pathway in endothelial cells

    Cyclodextrins (CDs) have utility for solubilizing and stabilizing drugs. Recently CDs have been foused as therapeutics for neurodegenerative diseases. However, some CDs are toxic when administered parenterally...

    Kwang-Hyun Park, Jong-Suk Kim, Eun-Mi Noh, Hong-Nu Yu… in Molecular & Cellular Toxicology (2013)

  5. No Access

    Article

    Membrane cholesterol is required for activity of Vibrio vulnificus cytolysin

    Vibrio vulnificus cytolysin (VVC) forms a pore in the plasma membrane and induces cytolysis of various cells including erythrocytes, neutrophil and endothelial cells. The cytolytic activity of VVC is inhibited by...

    Hong-Nu Yu, Young-Rae Lee, Kwang-Hyun Park, So-Young Rah… in Archives of Microbiology (2007)