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  1. Article

    Open Access

    Longitudinal assessment of interstitial lung abnormalities on CT in patients with COPD using artificial intelligence-based segmentation: a prospective observational study

    Interstitial lung abnormalities (ILAs) on CT may affect the clinical outcomes in patients with chronic obstructive pulmonary disease (COPD), but their quantification remains unestablished. This study examined ...

    Yusuke Shiraishi, Naoya Tanabe, Ryo Sakamoto, Tomoki Maetani in BMC Pulmonary Medicine (2024)

  2. Article

    Open Access

    Associations of pulmonary and extrapulmonary computed tomographic manifestations with impaired physical activity in symptomatic patients with chronic obstructive pulmonary disease

    In patients with chronic obstructive pulmonary disease (COPD), emphysema, airway disease, and extrapulmonary comorbidities may cause various symptoms and impair physical activity. To investigate the relative a...

    Yoko Hamakawa, Naoya Tanabe, Hiroshi Shima, Kunihiko Terada in Scientific Reports (2022)

  3. Article

    Open Access

    Relationship between peripheral airway function and patient-reported outcomes in COPD: a cross-sectional study

    Health status, dyspnea and psychological status are important clinical outcomes in chronic obstructive pulmonary disease (COPD). However, forced expiratory volume in one second (FEV1) measured by spirometry, the ...

    Akane Haruna, Toru Oga, Shigeo Muro, Tadashi Ohara, Susumu Sato in BMC Pulmonary Medicine (2010)

  4. No Access

    Chapter and Conference Paper

    Reconstitution of Hepatic Tissues Using Liver Stem Cells

    There is an increasing need for liver transplantation, and the demand has not been sufficiently met. The development of therapies such as liver cell transplantation and an artificial liver to replace liver tra...

    Toshihiro Sugiyama, Kunihiko Terada in Growth, Proliferation, and Apoptosis in Hepatocytes (2002)

  5. No Access

    Chapter

    Intracellular Copper Transport and ATP7B, the Wilson’s Disease Protein

    Copper is an essential trace metal for all living organisms because this metal serves as a cofactor for activating numerous enzymes critical for homeostasis. However, when copper exceeds the cellular needs, it...

    Kunihiko Terada, Toshihiro Sugiyama in Handbook of Copper Pharmacology and Toxicology (2002)

  6. No Access

    Chapter and Conference Paper

    Analysis of Gene Amplification in Human Esophageal Cancer

    The “multistep” of genetic alterations is necessary for cancer formation [1], but there are few reports dealing with both oncogenes and tumor suppressor genes in human esophageal cancer. To investigate the cor...

    Hiroyuki Suzuki, Shichisaburo Abo in Recent Advances in Diseases of the Esophag… (1993)