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Article
Open AccessLongitudinal assessment of interstitial lung abnormalities on CT in patients with COPD using artificial intelligence-based segmentation: a prospective observational study
Interstitial lung abnormalities (ILAs) on CT may affect the clinical outcomes in patients with chronic obstructive pulmonary disease (COPD), but their quantification remains unestablished. This study examined ...
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Article
Open AccessAssociations of pulmonary and extrapulmonary computed tomographic manifestations with impaired physical activity in symptomatic patients with chronic obstructive pulmonary disease
In patients with chronic obstructive pulmonary disease (COPD), emphysema, airway disease, and extrapulmonary comorbidities may cause various symptoms and impair physical activity. To investigate the relative a...
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Article
Open AccessRelationship between peripheral airway function and patient-reported outcomes in COPD: a cross-sectional study
Health status, dyspnea and psychological status are important clinical outcomes in chronic obstructive pulmonary disease (COPD). However, forced expiratory volume in one second (FEV1) measured by spirometry, the ...
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Chapter and Conference Paper
Reconstitution of Hepatic Tissues Using Liver Stem Cells
There is an increasing need for liver transplantation, and the demand has not been sufficiently met. The development of therapies such as liver cell transplantation and an artificial liver to replace liver tra...
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Chapter
Intracellular Copper Transport and ATP7B, the Wilson’s Disease Protein
Copper is an essential trace metal for all living organisms because this metal serves as a cofactor for activating numerous enzymes critical for homeostasis. However, when copper exceeds the cellular needs, it...
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Chapter and Conference Paper
Analysis of Gene Amplification in Human Esophageal Cancer
The “multistep” of genetic alterations is necessary for cancer formation [1], but there are few reports dealing with both oncogenes and tumor suppressor genes in human esophageal cancer. To investigate the cor...