102 Result(s)
-
Article
Open AccessAuthor Correction: A genetically encoded ratiometric indicator for tryptophan
-
Article
Open AccessCorrection: Chromosome-level genome provides insights into environmental adaptability and innate immunity in the common dolphin (Delphinus delphis)
-
Article
Open AccessMETTL3-mediated deficiency of lncRNA HAR1A drives non-small cell lung cancer growth and metastasis by promoting ANXA2 stabilization
We previously reported lncRNA HAR1A as a tumor suppressor in non-small cell lung cancer (NSCLC). However, the delicate working mechanisms of this lncRNA remain obscure. Herein, we demonstrated that the ectopic ex...
-
Article
Open AccessChromosome-level genome provides insights into environmental adaptability and innate immunity in the common dolphin (Delphinus delphis)
The common dolphin (Delphinus delphis) is widely distributed worldwide and well adapted to various habitats. Animal genomes store clues about their pasts, and can reveal the genes underlying their evolutionary su...
-
Article
Open AccessThe temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells
Many viruses enter host cells by hijacking endosomal trafficking. CapZ, a canonical actin cap** protein, participates in endosomal trafficking, yet its precise role in endocytosis and virus infection remains...
-
Article
Open AccessSmall-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers
Chromosomal instability (CIN) is a hallmark of cancer, caused by persistent errors in chromosome segregation during mitosis. Aggressive cancers like high-grade serous ovarian cancer (HGSOC) and triple-negative...
-
Article
Open AccessA genetically encoded ratiometric indicator for tryptophan
-
Article
Open AccessImmune landscape and redox imbalance during neurological disorders in COVID-19
The outbreak of Coronavirus Disease 2019 (COVID-19) has prompted the scientific community to explore potential treatments or vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the v...
-
Article
Open AccessDissecting peri-implantation development using cultured human embryos and embryo-like assembloids
Studies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge of peri-implantation lineage development as well as underlying mechanisms remains obscur...
-
Article
Open AccessResequencing of global Lotus corniculatus accessions reveals population distribution and genetic loci, associated with cyanogenic glycosides accumulation and growth traits
Lotus corniculatus is a widely distributed perennial legume whose great adaptability to different environments and resistance to barrenness make it an excellent forage and ecological restoration plant. However, i...
-
Article
Open AccessVAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling
The scaffold protein IRS-1 is an essential node in insulin/IGF signaling. It has long been recognized that the stability of IRS-1 is dependent on its endomembrane targeting. However, how IRS-1 targets the intr...
-
Article
Open AccessLysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance
Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challe...
-
Article
Open AccessCorrection: Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders
-
Article
Open AccessThe Sapria himalayana genome provides new insights into the lifestyle of endoparasitic plants
Sapria himalayana (Rafflesiaceae) is an endoparasitic plant characterized by a greatly reduced vegetative body and giant flowers; however, the mechanisms underlying its special lifestyle and greatly altered plant...
-
Article
Open AccessLkARF7 and LkARF19 overexpression promote adventitious root formation in a heterologous poplar model by positively regulating LkBBM1
Cuttage propagation involves adventitious root formation induced by auxin. In our previous study, Larix kaempferi BABY BOOM 1 (LkBBM1), which is known to regulate adventitious root formation, was affected by auxi...
-
Article
Open AccessCorrection: Activation of FXR and inhibition of EZH2 synergistically inhibit colorectal cancer through cooperatively accelerating FXR nuclear location and upregulating CDX2 expression
-
Article
Open AccessABX-1431 inhibits the development of endometrial adenocarcinoma and reverses progesterone resistance by targeting MGLL
Endometrial cancer is a common gynecological malignancy. With the onset of EC patients younger, conservative treatment with progesterone has become an important option for patients trying to preserve reproduct...
-
Article
Open AccessTulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish
Mutations in TUB-like protein 1 (TULP1) are associated with severe early-onset retinal degeneration in humans. However, the pathogenesis remains largely unknown. There are two homologous genes of TULP1 in zebrafi...
-
Article
Open AccessCharacteristics and potential functional effects of long insertions in Asian butternuts
Structural variants (SVs) play important roles in adaptation evolution and species diversification. Especially, in plants, many phenotypes of response to the environment were found to be associated with SVs. D...
-
Article
Open AccessSingle-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders
Immune non-responder after highly active antiretroviral therapy (HAART) is the main cause of opportunistic infections and high mortality in AIDS patients, but the mechanism underlying immune reconstitution fai...