146 Result(s)

Article

Correction: Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits

Jiaojiao Hao, Wenhua Fan, Yizhuo Li… in Journal of Experimental & Clinical Cancer … (2024)

Article

Retraction Note: Curcumin amends Ca^2 + dysregulation in microglia by suppressing the activation of P2 × 7 receptor

Zhen Wang, Weihua Ren, Fucheng Zhao, Yanru Han… in Molecular and Cellular Biochemistry (2024)

Article

Pragmatic nationwide master observational trial based on genomic alterations in advanced solid tumors: KOrean Precision Medicine Networking Group Study of MOlecular profiling guided therapy based on genomic alterations in advanced Solid tumors (KOSMOS)-II study protocol KCSG AL-22–09

Next-generation sequencing (NGS) has been introduced to many Korean institutions to support molecular diagnostics in cancer since 2017, when it became eligible for reimbursement by the National Health Insuranc...

Sun Young Kim, Jee Hyun Kim, Tae-Yong Kim, Sook Ryun Park, Shinkyo Yoon… in BMC Cancer (2024)

Article

PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis

Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing. However, the cardiac transcriptional regulation networks have not been systematically describ...

Liang Chen, Haotong Li, **aorui Liu… in Signal Transduction and Targeted Therapy (2024)

Article

A single-cell atlas enables map** of homeostatic cellular shifts in the adult human breast

Here we use single-cell RNA sequencing to compile a human breast cell atlas assembled from 55 donors that had undergone reduction mammoplasties or risk reduction mastectomies. From more than 800,000 cells we i...

Austin D. Reed, Sara Pensa, Adi Steif, Jack Stenning, Daniel J. Kunz… in Nature Genetics (2024)

Article

Tumor burden score and carcinoembryonic antigen predict outcomes in patients with intrahepatic cholangiocarcinoma following liver resection: a multi‑institutional analysis

The prognostic significance of tumor burden score (TBS) in relation to carcinoembryonic antigen (CEA) has not been investigated among patients undergoing hepatectomy for intrahepatic cholangiocarcinoma (ICC). ...

Jun Fu, Lifang Zheng, Shicuan Tang, Kongying Lin, Shuguo Zheng, **nyu Bi… in BMC Cancer (2024)

Article

Genetic and transcriptomic analyses of diffuse large B-cell lymphoma patients with poor outcomes within two years of diagnosis

Despite the improvements in clinical outcomes for DLBCL, a significant proportion of patients still face challenges with refractory/relapsed (R/R) disease after receiving first-line R-CHOP treatment. To furthe...

Weicheng Ren, Hui Wan, Sulaf Abd Own, Mattias Berglund, **anhuo Wang… in Leukemia (2024)

Article

Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy

The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing a crucial role in improving antitumor immunity through immune effector responses. Targeting the cGAS-STIN...

** Chen, Zhijie Xu, Tongfei Li, Abhimanyu Thakur, Yu Wen, Kui Zhang… in Biomarker Research (2024)

Article

A compendium of genetic regulatory effects across pig tissues

The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms...

**yan Teng, Yahui Gao, Hongwei Yin, Zhonghao Bai, Shuli Liu… in Nature Genetics (2024)

Article

Clinical application of ¹⁹²Ir High-Dose-Rate brachytherapy in metastatic lymph nodes of the neck

The objective of this study was to investigate the safety and effectiveness of high-dose-rate brachytherapy as a treatment modality for recurrent or residual neck metastatic lymph nodes following external radi...

Hongling Lu, Yunchuan Sun, Yan Gao, Li **ao, Jianxi Zhou, **aoming Yin… in Discover Oncology (2023)

Article

RIPK1 polymorphisms and expression levels: impact on genetic susceptibility and clinical outcome of epithelial ovarian cancer

The aim of this study was to explore the associations of RIPK1 polymorphisms, plasma levels and mRNA expression with susceptibility to epithelial ovarian cancer (EOC) and clinical outcome.

Xuedong Wang, Kui Deng, **g Tao, Juan Zou, Yiting Du, Li Dai in Cancer Cell International (2023)

Article

Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neu...

Ashok Iyaswamy, Abhimanyu Thakur, **n-Jie Guan… in Signal Transduction and Targeted Therapy (2023)

Article

Publisher Correction: Neoadjuvant adebrelimab in locally advanced resectable esophageal squamous cell carcinoma: a phase 1b trial

Jun Yin, **gnan Yuan, Yun** Li, Yong Fang, Ruoxi Wang, Heng Jiao… in Nature Medicine (2023)

Article

Using deep learning to predict survival outcome in non-surgical cervical cancer patients based on pathological images

We analyzed clinical features and the representative HE-stained pathologic images to predict 5-year overall survival via the deep-learning approach in cervical cancer patients in order to assist oncologists in...

Kun Zhang, Kui Sun, Caiyi Zhang, Kang Ren… in Journal of Cancer Research and Clinical On… (2023)

Article

Neoadjuvant adebrelimab in locally advanced resectable esophageal squamous cell carcinoma: a phase 1b trial

Overall survival (OS) benefits of neoadjuvant immunotherapy remain elusive in locally advanced esophageal squamous cell carcinomas (ESCC). Here, we reported the results of a phase 1b trial of neoadjuvant PD-L1...

Jun Yin, **gnan Yuan, Yun** Li, Yong Fang, Ruoxi Wang, Heng Jiao… in Nature Medicine (2023)