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Article
Open AccessThe effect of uveitis and undiagnosed spondyloarthritis: a systematic review and meta-analysis
Delay diagnosis of spondyloarthritis (SpA) is associated with poor functional ability and quality of life. Uveitis is the most frequent extraarticular manifestation in SpA, and its prevalence increases with lo...
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Article
Clinical and serological factors associated with lupus pericarditis: a case–control study
Lupus pericarditis, a common manifestation of systemic lupus erythematosus (SLE), can be fatal. We examined the prevalence of lupus pericarditis and its associated factors in a Taiwanese SLE cohort.
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Article
Open AccessAssessing the causal relationships between gout and hypertension: a bidirectional Mendelian randomisation study with coarsened exposures
Observational studies have demonstrated associations between gout and hypertension, but whether they are causal remains unclear. Our work aims to assess the causal relationship between gout and hypertension.
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Article
Open AccessFecal microbiota changes in NZB/W F1 mice after induction of lupus disease
The association between the gut microbiota and the development of lupus is unclear. We investigated alterations in the gut microbiota after induction of lupus in a murine model using viral peptide of human cyt...
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Article
Open AccessHuman cytomegalovirus pp65 peptide-induced autoantibodies cross-reacts with TAF9 protein and induces lupus-like autoimmunity in BALB/c mice
Human cytomegalovirus (HCMV) has been linked to the triggering of systemic lupus erythematosus (SLE). We proposed that B cell epitope region of HCMV phosphoprotein 65 (HCMVpp65)422–439 mimics an endogenous antige...
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Article
Open AccessImpact of urate-lowering drugs on the progression and recovery from chronic kidney disease among gout patients
This study investigates the association between exposure to urate-lowering drugs (ULDs) and progression and recovery from chronic kidney disease (CKD).
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Article
Open AccessA comprehensive analysis of the association of common variants of ABCG2 with gout
The objective of the present study was to determine whether there was an association between single nucleotide polymorphisms (SNPs) in ABCG2 and gout. We recruited 333 participants including 210 patients with gou...
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Article
Open AccessFamilial risk of systemic sclerosis and co-aggregation of autoimmune diseases in affected families
Systemic sclerosis (SSc) is a rare and devastating disease affecting skin and internal organs. Familial aggregation of SSc and co-aggregation with other autoimmune diseases is rarely reported.
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Article
Malignancy in dermatomyositis and polymyositis: analysis of 192 patients
This study aims to investigate the prevalence and predictive risk factors of malignancy in patients with polymyositis (PM) and dermatomyositis (DM). The medical records of 192 PM/DM patients followed up in a m...
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Article
The Trend of Inflammatory Bowel Diseases in Taiwan: A Population-Based Study
The purpose of this study was to estimate the sex- and age-specific incidence rates of inflammatory bowel diseases (IBD) in Taiwan. Site-specific cancer occurred in patients with IBD would be reported, too.
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Article
Open AccessEpidemiology and management of gout in Taiwan: a nationwide population study
Gout is the most common inflammatory arthritis worldwide and is the only type of chronic arthritis that potentially can be ‘cured’. However, data on gout incidence, prevalence and management, assessed at multi...
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Article
No overall increased risk of cancer in patients with rheumatoid arthritis: a nationwide dynamic cohort study in Taiwan
The association between rheumatoid arthritis (RA) and cancer is still controversial. This study aimed to estimate cancer incidence (both overall and site-specific) among patients with RA and to determine whet...
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Article
Open AccessAssociation of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies
Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is associated with severe morbidity and mortality and commonly seen in patients with diabetes mellitus (DM). The effect of metformin, the...
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Article
Survival impact of serum uric acid levels in children and adolescents
Evidence is limited on the association between hyperuricaemia and mortality in children and adolescents. This study was to investigate this association in the paediatric population. The study included children...
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Article
Rheumatoid arthritis prevalence, incidence, and mortality rates: a nationwide population study in Taiwan
There are few nationwide population studies on the epidemiology of rheumatoid arthritis (RA). Here, we present the epidemiologic features and mortality rates of RA in Taiwan. The catastrophic illness registry ...
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Article
Discontinuation of anti-TNF-α therapy in a Chinese cohort of patients with rheumatoid arthritis
The aim of this retrospective study was to examine the predictors of discontinuation of anti-tumor necrosis factor (TNF) therapy due to adverse events in Chinese patients with rheumatoid arthritis (RA). Anti-T...
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Article
Open AccessRisk of end-stage renal disease associated with gout: a nationwide population study
We explored the risk of end-stage renal disease (ESRD) among gout patients in a representative cohort in Taiwan.
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Article
Survival analysis of patients with dermatomyositis and polymyositis
To estimate the mortality rate and identify factors predicting survival in patients with polymyositis (PM) and dermatomyositis (DM). The medical records of 192 PM/DM patients who were treated at Chang Gung Mem...
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Article
Hyperuricemia and metabolic syndrome: associations with chronic kidney disease
The effects of serum uric acid (SUA) and metabolic syndrome on chronic kidney disease (CKD) remain controversial. This study grouped subjects according to a combination of their uric acid and metabolic syndrom...
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Article
Interstitial lung disease in polymyositis and dermatomyositis
The aim of the study was to estimate the prevalence, characteristics, and prognostic factors of interstitial lung disease (ILD) in patients with polymyositis (PM) and dermatomyositis (DM). The medical records ...
