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Open AccessNMR structure and functional studies of the fourth FAS1 domain of human periostin
Periostin is a matricellular protein that consists of several structural and functional domains, including EMILIN-like, four internal repeat fasciclin1 (FAS1) domains, and a carboxyl-terminal variable domain. ...
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Article
Open AccessImmunotherapeutic effects of recombinant colorectal cancer antigen produced in tomato fruits
The production of pharmacological vaccines in plants has been an important goal in the field of plant biotechnology. GA733-2, the protein that is also known as colorectal carcinoma (CRC)-associated antigen, is...
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Article
Open AccessTREM2 promotes natural killer cell development in CD3−CD122+NK1.1+ pNK cells
Triggering receptor expressed on myeloid cells 2 (TREM2) signaling is considered to regulate anti-inflammatory responses in macrophages, dendritic cell maturation, osteoclast development, induction of obesity,...
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Optimization of the human colorectal carcinoma antigen GA733-2 production in tobacco plants
The colorectal carcinoma-associated protein GA733-2 is one of the representative candidate protein for the development of plant-derived colorectal cancer vaccine. Despite of its significant importance for colo...
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Article
Open AccessProtective effects of Oxya chinensis sinuosa Mishchenko against ultraviolet B-induced photodamage in hairless mice
Edible insects, including Oxya chinensis sinuosa Mishchenko (Oc), which is consumed as food in Asia, are considered as a human food shortage alternative, and also as a preventive measure against environmental des...
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Article
Open AccessTREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia
TREM2 plays a critical role in the alleviation of Alzheimer’s disease by promoting Aβ phagocytosis by microglia, but the detailed molecular mechanism underlying TREM2-induced direct phagocytic activity of Aβ r...
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Article
Open AccessBlockade of Axl signaling ameliorates HPV16E6-mediated tumorigenecity of cervical cancer
Axl receptor tyrosine kinase is involved in the tumorigenesis and metastasis of many cancers. Axl expression was markedly higher in human papilloma virus type 16E6 (HPV16E6)-overexpressing HeLa (HE6F) cells an...
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Article
Axl signaling induces development of natural killer cells in vitro and in vivo
Natural killer (NK) cells have been well known to play a critical role in innate immunity, but they are also capable of regulating adaptive immunity through the induction of T cell-mediated memory response and...
