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Article
Open AccessProgression of vertebral deformity of prevalent vertebral fractures in the elderly: a population-based study
Little is known about the progression pattern of vertebral deformities in elderly patients with prevalent vertebral fractures. This population-based cohort study investigated the incidence, progression pattern...
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Article
Open AccessRegenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase
Intradiscal condoliase injection is an alternative therapeutic option for lumbar disc herniation (LDH). However, it is often associated with disc degeneration. Several in vivo studies have demonstrated the reg...
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Article
Open AccessA multicenter study of 1-year mortality and walking capacity after spinal fusion surgery for cervical fracture in elderly patients
The 1-year mortality and functional prognoses of patients who received surgery for cervical trauma in the elderly remains unclear. The aim of this study is to investigate the rates of, and factors associated w...
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Article
Open AccessIntradiscal injection of monosodium iodoacetate induces intervertebral disc degeneration in an experimental rabbit model
Establishing an optimal animal model for intervertebral disc (IVD) degeneration is essential for develo** new IVD therapies. The intra-articular injection of monosodium iodoacetate (MIA), which is commonly u...
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Article
Open AccessAssociation between non-traumatic vertebral fractures and adjacent discs degeneration: a cross-sectional study and literature review
Previous clinical studies reported that thoracolumbar vertebral fractures (VFs) associated with high energy spine trauma cause adjacent intervertebral disc (IVD) degeneration; however, the effect of non-trauma...
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Article
Open AccessEffect of diminished flow in rabbit lumbar arteries on intervertebral disc matrix changes using MRI T2-map** and histology
Impaired lumbar artery flow has been reported in clinical and epidemiological studies to be associated with low back pain and lumbar disc degeneration. However, it has not been experimentally demonstrated that...
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Article
Open AccessEndplate and intervertebral disc injuries in acute and single level osteoporotic vertebral fractures: is there any association with the process of bone healing?
The endplate-intervertebral disc (IVD) complex is closely interrelated with the vertebral body (VB) in the structural integrity of the anterior spinal column, including biomechanical and biological functions. ...
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Article
Open AccessExpression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration
The expression of the receptor activator of nuclear factor kappa B (RANK) /RANK ligand (RANKL) /osteoprotegerin (OPG) system and its association with the progression of intervertebral disc (IVD) degeneration h...
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Open AccessMorphology of intervertebral disc ruptures evaluated by vacuum phenomenon using multi-detector computed tomography: association with lumbar disc degeneration and canal stenosis
The progression of intervertebral disc (IVD) degeneration leads to rupture within IVD tissues. The location and appearance of areas of gaseous radiolucency in the IVD, known as vacuum phenomena (VPs), are cons...
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Article
Open AccessRANK/RANKL/OPG system in the intervertebral disc
The receptor activator of NF-κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in ...
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Article
Open AccessRisk factors for lumbar intervertebral disc height narrowing: a population-based longitudinal study in the elderly
The progression of disc degeneration is generally believed to be associated with low back pain and/or degenerative lumbar diseases, especially in the elderly. The purpose of this study was to quantitatively ev...
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Article
Open AccessExtradural cryptococcoma at the sacral spine without bone involvement in an immunocompetent patient
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Article
Open AccessProtective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb
Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and damage to skeletal muscle. The purposes of this study were 1) to assess the histological findings of ...
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Article
Open AccessEffect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study
Platelet-rich plasma (PRP) is a fraction of plasma in which several growth factors are concentrated at high levels. The active soluble releasate isolated following platelet activation of PRP (PRP-releasate) ha...
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Article
Distribution and role of tenascin-C in human osteoarthritic cartilage
Tenascin-C (TN-C) is expressed in the cartilage of osteoarthritis (OA). We examined whether TN-C was involved in cartilage repair of the diseased joints. Human articular cartilage samples were obtained from pa...
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Open AccessDirection of the formation of anterior lumbar vertebral osteophytes
X-ray images of lumbar degenerative diseases often show not only claw osteophytes, but also pairs of osteophytes that form in a direction away from the adjacent disc. We have investigated the direction of the ...