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  1. No Access

    Article

    Neurological recovery rate and predictive factors of incomplete AIS grade C spinal cord injury in the older aged population

    Retrospective cohort study.

    Koji Tamai, Hidetomi Terai, Hiroaki Nakamura, Noriaki Yokogawa in Spinal Cord (2024)

  2. Article

    Open Access

    Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury

    This retrospective cohort study established malnutrition’s impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with trau...

    Koji Tamai, Hidetomi Terai, Hiroaki Nakamura, Noriaki Yokogawa in Scientific Reports (2024)

  3. Article

    Open Access

    Progression of vertebral deformity of prevalent vertebral fractures in the elderly: a population-based study

    Little is known about the progression pattern of vertebral deformities in elderly patients with prevalent vertebral fractures. This population-based cohort study investigated the incidence, progression pattern...

    Koji Akeda, Kazuma Nakase, Junichi Yamada in BMC Musculoskeletal Disorders (2024)

  4. No Access

    Article

    Central sensitization as a predictive factor for the surgical outcome in patients with lumbar spinal stenosis: a multicenter prospective study

    The impact of central sensitization (CS) on neurological symptoms and surgical outcomes in patients with lumbar spinal stenosis (LSS) remains unknown. This study aimed to investigate the influence of preoperat...

    Koji Akeda, Junichi Yamada, Norihiko Takegami, Tatsuhiko Fujiwara in European Spine Journal (2023)

  5. Article

    Open Access

    Regenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase

    Intradiscal condoliase injection is an alternative therapeutic option for lumbar disc herniation (LDH). However, it is often associated with disc degeneration. Several in vivo studies have demonstrated the reg...

    Takahiro Hasegawa, Koji Akeda, Junichi Yamada in Arthritis Research & Therapy (2023)

  6. No Access

    Article

    Prognostic impact of respiratory dysfunction in elderly patients with cervical spinal cord injury and/or fractures: a multicenter survey

    To investigate the impact of early post-injury respiratory dysfunction for neurological and ambulatory ability recovery in patients with cervical spinal cord injury (SCI) and/or fractures.

    Ryosuke Hirota, Yoshinori Terashima, Hirofumi Ohnishi in European Spine Journal (2023)

  7. Article

    Open Access

    Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament

    Although the incidence of cervical spinal cord injury (CSCI) with ossification of the posterior longitudinal ligament (OPLL) has increased in older adults, its etiology and neurological outcomes remain unknown...

    Shun Okuwaki, Toru Funayama, Masao Koda, Fumihiko Eto, Akihiro Yamaji in Scientific Reports (2023)

  8. Article

    Change in prevalence of vertebral fractures over two decades: a Japanese medical examination-based study

    Although remarkable progress has been made in osteoporosis treatment over the last two decades, no study has reported the change in the prevalence of vertebral fractures (VFs) during this time. This study aime...

    Junichi Yamada, Koji Akeda, Norihiko Takegami in Journal of Bone and Mineral Metabolism (2023)

  9. Article

    Open Access

    Differences in clinical characteristics of cervical spine injuries in older adults by external causes: a multicenter study of 1512 cases

    Although traumatic cervical spine injuries in older adults are commonly caused by minor traumas, such as ground-level falls, their prognosis is often unfavorable. Studies examining the clinical characteristics...

    Noriaki Yokogawa, Satoshi Kato, Takeshi Sasagawa, Hiroyuki Hayashi in Scientific Reports (2022)

  10. Article

    Open Access

    A multicenter study of 1-year mortality and walking capacity after spinal fusion surgery for cervical fracture in elderly patients

    The 1-year mortality and functional prognoses of patients who received surgery for cervical trauma in the elderly remains unclear. The aim of this study is to investigate the rates of, and factors associated w...

    Takeshi Sasagawa, Noriaki Yokogawa, Hiroyuki Hayashi in BMC Musculoskeletal Disorders (2022)

  11. Article

    Open Access

    Intradiscal injection of monosodium iodoacetate induces intervertebral disc degeneration in an experimental rabbit model

    Establishing an optimal animal model for intervertebral disc (IVD) degeneration is essential for develo** new IVD therapies. The intra-articular injection of monosodium iodoacetate (MIA), which is commonly u...

    Takao Sudo, Koji Akeda, Koki Kawaguchi, Takahiro Hasegawa in Arthritis Research & Therapy (2021)

  12. No Access

    Article

    Three-dimensional computed tomographic evaluation of lateral lumbar interbody fusion: morphometric change of intervertebral structure

    Two-dimensional (2D) analyses of intervertebral disc (IVD) height and foramen measurements following lateral lumbar interbody fusion (LLIF) have been reported. However, three-dimensional (3D) morphometric anal...

    Koji Akeda, Kevin Cheng, Edward Abarado, Norihiko Takegami in European Spine Journal (2021)

  13. Article

    Open Access

    Association between non-traumatic vertebral fractures and adjacent discs degeneration: a cross-sectional study and literature review

    Previous clinical studies reported that thoracolumbar vertebral fractures (VFs) associated with high energy spine trauma cause adjacent intervertebral disc (IVD) degeneration; however, the effect of non-trauma...

    Norihiko Takegami, Koji Akeda, Koichiro Murata in BMC Musculoskeletal Disorders (2020)

  14. Article

    Open Access

    Cervical schwannoma in the early stage of pregnancy: a case report

    Although spinal schwannomas generally grow very slowly, it has been reported that these clinical growths and their associated neurological symptoms accelerate during pregnancy. Because these cases are rare, su...

    Koki Kawaguchi, Koji Akeda, Norihiko Takegami, Tatsuya Kurata in BMC Surgery (2020)

  15. Article

    Open Access

    Effect of diminished flow in rabbit lumbar arteries on intervertebral disc matrix changes using MRI T2-map** and histology

    Impaired lumbar artery flow has been reported in clinical and epidemiological studies to be associated with low back pain and lumbar disc degeneration. However, it has not been experimentally demonstrated that...

    Takao Imanishi, Koji Akeda, Koichiro Murata, Akihiro Sudo in BMC Musculoskeletal Disorders (2019)

  16. Article

    Open Access

    Endplate and intervertebral disc injuries in acute and single level osteoporotic vertebral fractures: is there any association with the process of bone healing?

    The endplate-intervertebral disc (IVD) complex is closely interrelated with the vertebral body (VB) in the structural integrity of the anterior spinal column, including biomechanical and biological functions. ...

    Tatsuhiko Fujiwara, Koji Akeda, Junichi Yamada in BMC Musculoskeletal Disorders (2019)

  17. Article

    Open Access

    Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration

    The expression of the receptor activator of nuclear factor kappa B (RANK) /RANK ligand (RANKL) /osteoprotegerin (OPG) system and its association with the progression of intervertebral disc (IVD) degeneration h...

    Tomohiko Sano, Koji Akeda, Junichi Yamada in BMC Musculoskeletal Disorders (2019)

  18. Article

    Open Access

    Morphology of intervertebral disc ruptures evaluated by vacuum phenomenon using multi-detector computed tomography: association with lumbar disc degeneration and canal stenosis

    The progression of intervertebral disc (IVD) degeneration leads to rupture within IVD tissues. The location and appearance of areas of gaseous radiolucency in the IVD, known as vacuum phenomena (VPs), are cons...

    Koichiro Murata, Koji Akeda, Norihiko Takegami in BMC Musculoskeletal Disorders (2018)

  19. Article

    Open Access

    RANK/RANKL/OPG system in the intervertebral disc

    The receptor activator of NF-κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in ...

    Norihiko Takegami, Koji Akeda, Junichi Yamada in Arthritis Research & Therapy (2017)

  20. Article

    Open Access

    Atlantoaxial rotatory fixation as a rare complication from head positioning in otologic surgery: Report of two cases in young children

    Atlantoaxial rotatory fixation is a condition in which the first and second vertebrae of the cervical spine become interlocked in a rotated position. This condition can result in serious consequences and thus ...

    Hiroshi Sakaida, Koji Akeda, Akihiro Sudo, Kazuhiko Takeuchi in Patient Safety in Surgery (2017)

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