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  1. Article

    Open Access

    Progression of vertebral deformity of prevalent vertebral fractures in the elderly: a population-based study

    Little is known about the progression pattern of vertebral deformities in elderly patients with prevalent vertebral fractures. This population-based cohort study investigated the incidence, progression pattern...

    Koji Akeda, Kazuma Nakase, Junichi Yamada in BMC Musculoskeletal Disorders (2024)

  2. Article

    Open Access

    A multicenter study of 1-year mortality and walking capacity after spinal fusion surgery for cervical fracture in elderly patients

    The 1-year mortality and functional prognoses of patients who received surgery for cervical trauma in the elderly remains unclear. The aim of this study is to investigate the rates of, and factors associated w...

    Takeshi Sasagawa, Noriaki Yokogawa, Hiroyuki Hayashi in BMC Musculoskeletal Disorders (2022)

  3. Article

    Open Access

    Association between non-traumatic vertebral fractures and adjacent discs degeneration: a cross-sectional study and literature review

    Previous clinical studies reported that thoracolumbar vertebral fractures (VFs) associated with high energy spine trauma cause adjacent intervertebral disc (IVD) degeneration; however, the effect of non-trauma...

    Norihiko Takegami, Koji Akeda, Koichiro Murata in BMC Musculoskeletal Disorders (2020)

  4. Article

    Open Access

    Effect of diminished flow in rabbit lumbar arteries on intervertebral disc matrix changes using MRI T2-map** and histology

    Impaired lumbar artery flow has been reported in clinical and epidemiological studies to be associated with low back pain and lumbar disc degeneration. However, it has not been experimentally demonstrated that...

    Takao Imanishi, Koji Akeda, Koichiro Murata, Akihiro Sudo in BMC Musculoskeletal Disorders (2019)

  5. Article

    Open Access

    Endplate and intervertebral disc injuries in acute and single level osteoporotic vertebral fractures: is there any association with the process of bone healing?

    The endplate-intervertebral disc (IVD) complex is closely interrelated with the vertebral body (VB) in the structural integrity of the anterior spinal column, including biomechanical and biological functions. ...

    Tatsuhiko Fujiwara, Koji Akeda, Junichi Yamada in BMC Musculoskeletal Disorders (2019)

  6. Article

    Open Access

    Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration

    The expression of the receptor activator of nuclear factor kappa B (RANK) /RANK ligand (RANKL) /osteoprotegerin (OPG) system and its association with the progression of intervertebral disc (IVD) degeneration h...

    Tomohiko Sano, Koji Akeda, Junichi Yamada in BMC Musculoskeletal Disorders (2019)

  7. Article

    Open Access

    Morphology of intervertebral disc ruptures evaluated by vacuum phenomenon using multi-detector computed tomography: association with lumbar disc degeneration and canal stenosis

    The progression of intervertebral disc (IVD) degeneration leads to rupture within IVD tissues. The location and appearance of areas of gaseous radiolucency in the IVD, known as vacuum phenomena (VPs), are cons...

    Koichiro Murata, Koji Akeda, Norihiko Takegami in BMC Musculoskeletal Disorders (2018)

  8. Article

    Open Access

    Risk factors for lumbar intervertebral disc height narrowing: a population-based longitudinal study in the elderly

    The progression of disc degeneration is generally believed to be associated with low back pain and/or degenerative lumbar diseases, especially in the elderly. The purpose of this study was to quantitatively ev...

    Koji Akeda, Tomomi Yamada, Nozomu Inoue, Akinobu Nishimura in BMC Musculoskeletal Disorders (2015)

  9. Article

    Open Access

    Protective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb

    Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and damage to skeletal muscle. The purposes of this study were 1) to assess the histological findings of ...

    Kazuichiro Hori, Masaya Tsujii, Takahiro Iino in BMC Musculoskeletal Disorders (2013)

  10. Article

    Open Access

    Direction of the formation of anterior lumbar vertebral osteophytes

    X-ray images of lumbar degenerative diseases often show not only claw osteophytes, but also pairs of osteophytes that form in a direction away from the adjacent disc. We have investigated the direction of the ...

    Yuichi Kasai, Eiji Kawakita, Toshihiko Sakakibara in BMC Musculoskeletal Disorders (2009)