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Article
Prognostic factors and significance of postoperative adjuvant chemotherapy in patients with advanced gastric cancer undergoing neoadjuvant chemotherapy followed by gastrectomy
In Japan, gastrectomy with D2 lymph node dissection and postoperative adjuvant chemotherapy are the standard treatments for locally advanced gastric cancer. Neoadjuvant chemotherapy (NAC) is not affected by po...
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Article
Open AccessPhenotypic and molecular characterization of novel pulmonary adenocarcinoma cell lines established from a dog
Canine pulmonary adenocarcinoma (PAC) resembles human lung tumors in never-smokers, but it is rarer than human pulmonary adenocarcinoma. Therefore, research on canine PAC is challenging. In the present study, ...
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Article
Inhibitor of protein kinase N3 suppresses excessive bone resorption in ovariectomized mice
The long-term inhibition of bone resorption suppresses new bone formation because these processes are coupled during physiological bone remodeling. The development of anti-bone-resorbing agents that do not sup...
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Article
Open AccessRobotic-assisted proximal gastrectomy using the double-flap technique for early gastric cancer with situs inversus totalis: a case report
The robotic system has been applied in the treatment of gastric cancer (GC), and the procedure has been found to be safe and feasible. Situs inversus totalis (SIT) is a relatively rare autosomal recessive cong...
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Article
Open AccessSafety and efficacy of laparoscopic repeat liver resection and re-operation for liver tumor
Laparoscopic liver resection (LLR) has been reported as a safe, minimally invasive, and effective surgery for the management of liver tumor. However, the efficacy and safety of laparoscopic repeat liver resect...
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Article
Neutropenia is an indicator of outcomes in metastatic colorectal cancer patients treated with FTD/TPI plus bevacizumab: a retrospective study
Trifluridine/tipiracil (FTD/TPI) improves the overall survival (OS) of metastatic colorectal cancer (mCRC) patients. Additionally, FTD/TPI plus bevacizumab (BEV) has demonstrated promising efficacy for mCRC pa...
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Article
Open AccessSclerostin expression in trabecular bone is downregulated by osteoclasts
Bone tissues have trabecular bone with a high bone turnover and cortical bone with a low turnover. The mechanisms by which the turnover rate of these bone tissues is determined remain unclear. Osteocytes secre...
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Article
The Shisa3 knockout mouse exhibits normal bone phenotype
Wnt signaling is important for both skeletal development and bone disease, with Wnt inhibitory factors playing critical roles in bone metabolism. SHISA3 blocks the maturation and transportation of Frizzled rec...
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Article
Open AccessVitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment
To evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a deno...
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Article
Open AccessTwo-year clinical outcome of denosumab treatment alone and in combination with teriparatide in Japanese treatment-naive postmenopausal osteoporotic women
This randomized prospective study aimed to evaluate the clinical outcome of denosumab treatment alone and in combination with teriparatide in treatment-naive postmenopausal Japanese female patients with osteop...
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Article
Laparoscopic lymphadenectomy around the left renal vein (16a2lat) by tunneling under the pancreas for advanced Siewert type II adenocarcinoma
The para-aortic lymph nodes around the left renal vein (16a2lat) are now considered important to target in the treatment of advanced adenocarcinoma of the esophagogastric junction. We describe a laparoscopic a...
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Article
Open AccessSingle-site laparoscopic right hemicolectomy for acute cecal volvulus: a case report
Cecal volvulus is an uncommon cause of acute abdomen in patients. Cecal volvulus is currently treated mostly with right hemicolectomy with laparotomy, which is an invasive surgical procedure. Less invasive tec...
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Article
Effects of ghrelin administration on the early postoperative inflammatory response after esophagectomy
Ghrelin is a unique gastric hormone, which has pleiotropic biological functions, including anti-inflammatory effects. The aim of this study was to investigate the effects of administering ghrelin on reducing p...
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Article
Clinical application of ghrelin in the field of surgery
Ghrelin was discovered as an intrinsic ligand for the growth hormone (GH)-secretagogue receptor (GHS-R) in 1999. The endogenous production of ghrelin occurs mainly in the stomach. Ghrelin has multiple function...
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Article
Clinical application of ghrelin administration for gastric cancer patients undergoing gastrectomy
Loss of body weight is a common (and the most serious) sequela after gastrectomy. It impairs quality of life, increases various diseases including infection, and may affect long-term survival. Ghrelin, an intr...
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Article
Rhizoid differentiation of Spirogyra is regulated by substratum
Some species of Spirogyra can anchor to substratum with rod- or rosette-shaped rhizoid (hapteron). The rhizoid differentiation can be induced by cutting algal filaments in a laboratory. Requirement of contact sti...
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Chapter and Conference Paper
Risk Evaluation for Personal Identity Management Based on Privacy Attribute Ontology
Identity providers are becoming popular for distributed authentication and distributed identity management. Users’ privacy attributes are stored at an identity provider and they are released to a service provi...
