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Article
Open AccessCorrection to: Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice
Correction to: NPG Asia Materials (2018) https://doi.org/10.1038/s41427-018-0014-9 published online on 16 April 2018
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Article
Open AccessDisease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice
Several mutant mice have been generated to model connexin (Cx)-linked skin diseases; however, the role of connexins in skin maintenance and during wound healing remains to be fully elucidated. Here we generate...
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Article
Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis
Skeletal muscles of patients with Duchenne muscular dystrophy (DMD) show numerous alterations including inflammation, apoptosis, and necrosis of myofibers. However, the molecular mechanism that explains these ...
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Article
Cell-type-specific expression pattern of ceramide synthase 2 protein in mouse tissues
Ceramide synthase 2 (CerS2) catalyzes the synthesis of dihydroceramides from dihydrosphingosine and very long fatty acyl (C22–C24)-CoAs. CerS2-deficient (gene trap) mice were reported to exhibit myelin and beh...
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Article
Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels
The cardiac intercalated disc harbors mechanical and electrical junctions as well as ion channel complexes mediating propagation of electrical impulses. Cardiac connexin43 (Cx43) co-localizes and interacts wit...
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Article
Open AccessExpression of connexin genes in the human retina
Gap junction channels allow direct metabolically and electrical coupling between adjacent cells in various mammalian tissues. Each channel is composed of 12 protein subunits, termed connexins (Cx). In the mous...
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Article
Open AccessConnexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium
The modulation of gap junctional communication between tumor cells and between tumor and vascular endothelial cells during tumorigenesis and metastasis is complex. The notion of a role for loss of gap junction...
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Article
Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia
Ventricular tachyarrhythmias are the main cause of sudden death in patients after myocardial infarction. Here we show that transplantation of embryonic cardiomyocytes (eCMs) in myocardial infarcts protects aga...
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Article
Some Oculodentodigital Dysplasia-Associated Cx43 Mutations Cause Increased Hemichannel Activity in Addition to Deficient Gap Junction Channels
Oculodentodigital dysplasia (ODDD) is a dominantly inherited human disorder associated with different symptoms like craniofacial anomalies, syndactyly and heart dysfunction. ODDD is caused by mutations in the GJA...
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Article
Open AccessReplacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart
In order to further distinguish unique from general functions of connexin43, we have generated mice in which the coding region of connexin43 was replaced by that of connexin26.
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Article
Ablation of connexin43 in smooth muscle cells of the mouse intestine: functional insights into physiology and morphology
Connexin43 (Cx43) gap-junction channels are highly abundant in intestinal smooth muscle but their functional impact has not been studied so far. Here, we have aimed to elucidate the functional role of Cx43 in ...
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Article
Expression and functions of neuronal gap junctions
Gap-junctional communication between neurons was first described several decades ago in crayfish, and was later studied by electrophysiological means in mammal...
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Chapter
Connexin and Pannexin Genes in the Mouse and Human Genome
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Chapter
Essential Role of Gap Junctions During Development and Regeneration of Skeletal Muscle
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Article
Expression of the connexin43- and connexin45-encoding genes in the develo** and mature mouse inner ear
Intercellular communication through gap junctions is crucial for proper functioning of the inner ear. Indeed, mutations in several connexin genes have been found to cause hearing loss. In the inner ear, only t...
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Article
The electrical behaviour of rat connexin46 gap junction channels expressed in transfected HeLa cells
Pairs of human HeLa cells expressing rat connexin46 were used to study the electrical properties of gap junction channels with the dual voltage-clamp method. The steady-state conductance (g j,ss) had a bell-shape...
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Article
Human connexin26 (GJB2) deafness mutations affect the function of gap junction channels at different levels of protein expression.
Mutations in the connexin26 (GJB2) gene account for about half of inherited non-syndromic deafness cases in Western countries. The connexin26 protein is a subunit of gap junctions that form a network of inter...
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Article
Immunohistochemical detection of the neuronal connexin36 in the mouse central nervous system in comparison to connexin36-deficient tissues
Investigating the spatial and temporal expression of connexin36 (Cx36) protein in neuronal tissue is of prime importance to understand the molecular mechanisms underlying extensive electrical coupling. Altho...
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Article
Quantitative analysis of gap-junctional intercellular communication in precision-cut mouse liver slices
Direct intercellular communication through gap junction channels is involved in the maintenance of tissue homeostasis and suppression of carcinogenesis. Gap-junctional communication is often altered in tumor ...
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Article
Dilated bile canaliculi and attenuated decrease of nerve-dependent bile secretion in connexin32-deficient mouse liver
Gap junction channels in the rodent liver are composed of connexin26 (Cx26) and connexin32 (Cx32) proteins. Gap junctional intercellular communication in the mouse liver enhances the effects of hormonal or sy...
