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Characterization of sphingomyelinase activity released by thrombin-stimulated platelets
In this study we report that human platelets display neutral (nSMase) and acid sphingomyelinase (aSMase) as well as acid ceramidase (aCerase) activity. Cell activation by thrombin resulted in a marked decrease...
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Article
Fas/CD95/Apo-I activates the acidic sphingomyelinase via Caspases
Fas/CD95/Apo-I has been shown to stimulate a variety of molecules including several members of the caspase family and the acidic sphingomyelinase (Martin and Green 1995; Gulbins et al, 1995). Here, we demonstrate...