-
Article
Open AccessMidregional Proatrial Natriuretic Peptide (MRproANP) is associated with vertebral fractures and low bone density in patients with chronic obstructive pulmonary disease (COPD)
Patients with COPD are often affected by loss of bone mineral density (BMD) and osteoporotic fractures. Natriuretic peptides (NP) are known as cardiac markers, but have also been linked to fragility-associated...
-
Article
Geschlechtsspezifische Aspekte bei der chronisch obstruktiven Lungenerkrankung
In den kommenden Jahren wird die Zahl der Fälle von Patienten und Patientinnen mit chronisch obstruktiver Lungenerkrankung (COPD) weiter ansteigen, wobei der Anstieg bei Frauen und in Regionen mit niedrigen un...
-
Article
Open AccessPeriod of hospitalization and mortality in transferred versus non-transferred COVID-19 patients: results from Germany
COVID-19 was a challenge for health-care systems worldwide, causing large numbers of hospitalizations and inter-hospital transfers. We studied whether transfer, as well as its reason, was associated with the d...
-
Article
Open AccessEffects of triple therapy on disease burden in patients of GOLD groups C and D: results from the observational COPD cohort COSYCONET
Randomized controlled trials described beneficial effects of inhaled triple therapy (LABA/LAMA/ICS) in patients with chronic obstructive pulmonary disease (COPD) and high risk of exacerbations. We studied whet...
-
Article
Open AccessTumor seeding following CT- guided transthoracic needle biopsy in lung cancer. A case report
As a result of advances in the treatment of lung cancer, the life expectancy of lung cancer patients has improved significantly, but it remains the leading cause of cancer death worldwide. For decades, most of...
-
Article
Open AccessGender-specific differences in COPD symptoms and their impact for the diagnosis of cardiac comorbidities
In chronic obstructive pulmonary disease (COPD), gender-specific differences in the prevalence of symptoms and comorbidity are known.
-
Article
Open AccessCardiovascular predictors of mortality and exacerbations in patients with COPD
In chronic obstructive pulmonary disease (COPD), comorbidities and worse functional status predict worse outcomes, but how these predictors compare with regard to different outcomes is not well studied. We thu...
-
Article
A simple risk score for mortality including the PCR Ct value upon admission in patients hospitalized due to COVID-19
To develop a simple score for the outcomes from COVID-19 that integrates information obtained at the time of admission including the Ct value (cycle threshold) for SARS-CoV-2.
-
Article
Open AccessSex-specific associations of comorbidome and pulmorbidome with mortality in chronic obstructive pulmonary disease: results from COSYCONET
In patients with COPD, it has not been comprehensively assessed whether the predictive value of comorbidities for mortality differs between men and women. We therefore aimed to examine sex differences of COPD ...
-
Article
Open AccessConsequences of the COVID-19 pandemic on lung cancer care and patient health in a German lung cancer center: results from a cross-sectional questionnaire
The novel coronavirus SARS-CoV-2 has caused a global COVID-19 pandemic, leading to worldwide changes in public health measures. In addition to changes in the public sector (lockdowns, contact restrictions), ho...
-
Article
Open AccessReduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment
We studied whether in patients with COPD the use of metformin for diabetes treatment was linked to a pattern of lung function decline consistent with the hypothesis of anti-aging effects of metformin. Patients...
-
Article
Open AccessPrediction of lung emphysema in COPD by spirometry and clinical symptoms: results from COSYCONET
Lung emphysema is an important phenotype of chronic obstructive pulmonary disease (COPD), and CT scanning is strongly recommended to establish the diagnosis. This study aimed to identify criteria by which phys...
-
Article
Open AccessCorrection to: Treatment Sequencing for Anaplastic Lymphoma Kinase-Rearranged Non-Small-Cell Lung Cancer
A correction to this paper has been published: https://doi.org/10.1007/s40265-021-01536-8
-
Article
Open AccessSystemic inflammation and pro-inflammatory cytokine profile predict response to checkpoint inhibitor treatment in NSCLC: a prospective study
Treatment with single agent immune checkpoint inhibitors (ICIs) has tremendously changed second line therapy in NSCLC. However, there are still no reliable biomarkers predicting response and survival in this g...
-
Article
Open AccessTreatment Sequencing for Anaplastic Lymphoma Kinase-Rearranged Non-Small-Cell Lung Cancer
Non-small-cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases and is the leading cause of cancer-related deaths. Most NSCLC patients are diagnosed with advanced disease and require systemi...
-
Article
Open AccessHealth-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort
Forced expiratory volume in one second (FEV1) characterizes the pathophysiology of COPD and different trajectories of FEV1 decline have been observed in patients with COPD (e.g. gradual or episodic). There is lim...
-
Living Reference Work Entry In depth
Endoskopische Diagnostik bei thorakalen Tumoren
Basierend auf den Empfehlungen der S3-Leitlinie zur Behandlung des Lungenkarzinoms beinhaltet die Basisdiagnostik bei klinischem oder radiologischem Verdacht auf ein Lungenkarzinom neben Anamnese, klinischen u...
-
Article
Open AccessThe association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort
Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).
-
Article
Response assessment in non-small cell lung cancer immunotherapy: initial experiences in utilizing FDG PET/CT and the PD-1 blocker nivolumab
Most Non-Small-Cell lung cancer (NSCLC) patients need systemic treatment. Immunotherapy is now current standard in first- and second-line treatment. In all pivotal studies, staging was performed using conventi...
-
Article
Open AccessEffects of airway obstruction and hyperinflation on electrocardiographic axes in COPD
COPD influences cardiac function and morphology. Changes of the electrical heart axes have been largely attributed to a supposed increased right heart load in the past, whereas a potential involvement of the l...
