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Article
Open AccessHigh mobility group box 1 and a network of other biomolecules influence fatigue in patients with Crohn’s disease
Fatigue is common in patients with chronic inflammatory and autoimmune diseases, often with a severe impact on the patient’s daily life. From a biological point of view, fatigue can be regarded as an element o...
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Article
Fatigue in patients with plaque-type psoriasis: lack of an association with plasma cytokines
Fatigue is common in patients with psoriasis, and cytokines have been postulated to influence fatigue.
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Article
Open AccessInterleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome
Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ...
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Article
Open AccessExpression of selected genes isolated from whole blood, liver and obex in lambs with experimental classical scrapie and healthy controls, showing a systemic innate immune response at the clinical end-stage
Incubation period, disease progression, pathology and clinical presentation of classical scrapie in sheep are highly dependent on PRNP genotype, time and route of inoculation and prion strain. Our experimental mo...
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Article
Open AccessInvestigation of serum protein profiles in scrapie infected sheep by means of SELDI-TOF-MS and multivariate data analysis
Classical scrapie in sheep is a fatal neurodegenerative disease associated with the conversion PrPC to PrPSc. Much is known about genetic susceptibility, uptake and dissemination of PrPSc in the body, but many as...
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Article
Open AccessPresence of an acute phase response in sheep with clinical classical scrapie
Work with experimental scrapie in sheep has been performed on-site for many years including studies on PrPSc dissemination and histopathology of organs and tissues both at preclinical and clinical stages. In this...
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Article
Open AccessVariant -and individual dependent nature of persistent Anaplasma phagocytophilum infection
Anaplasma phagocytophilum is the causative agent of tick-borne fever in ruminants and human granulocytotropic anaplasmosis (HGA). The bacterium is able to survive for several months in immune-competent sheep by m...
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Article
Open AccessSuperinfection occurs in Anaplasma phagocytophilum infected sheep irrespective of infection phase and protection status
Anaplasma phagocytophilum infection in domestic ruminants is widespread in the coastal areas of southern Norway. The bacteria may persist in mammalian hosts. Several genetic variants of A. phagocytophilum exist. ...
