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    Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice

    Flutamide, a nonsteroidal antiandrogen used for treatment of prostate cancer, causes a temporary increase in transaminase and in some cases severe liver dysfunction. It is dominantly metabolized by cytochrome ...

    Yasushi Matsuzaki, Daichi Nagai, Eiji Ichimura, Rika Goda… in Journal of Gastroenterology (2006)