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  1. Article

    Open Access

    Real-World Safety and Efficacy of Biosimilar CT-P13 in Patients with Immune-Mediated Inflammatory Diseases: Integrated Analysis of Three Japanese Prospective Observational Studies

    Biosimilar CT-P13 was approved with limited data from clinical trials compared to the originator infliximab in biologic-naïve patients with rheumatoid arthritis. Three prospective post-marketing surveillance s...

    Tsutomu Takeuchi, Kiyohiro Nishikawa, Fumika Yamada, Akimichi Morita… in Drug Safety (2023)

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    Article

    Pharmacokinetic analysis of a combined chemoendocrine treatment with paclitaxel and toremifene for metastatic breast cancer

    Multidrug resistance protein could be a target for improving the efficacy of paclitaxel (PXL). Toremifene (TOR) may moderate P-gp-related drug resistance in vitro. Some P-gp moderators may change the pharmacok...

    Toshiaki Saeki, Atsushi Okita, Kenjiro Aogi, Tomokazu Kakishita… in Breast Cancer (2009)

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    Article

    Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice

    Flutamide, a nonsteroidal antiandrogen used for treatment of prostate cancer, causes a temporary increase in transaminase and in some cases severe liver dysfunction. It is dominantly metabolized by cytochrome ...

    Yasushi Matsuzaki, Daichi Nagai, Eiji Ichimura, Rika Goda… in Journal of Gastroenterology (2006)