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Molecular markers in glioma

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  1. Article

    Open Access

    Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities

    There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discern function by using cell lines transduced with exo...

    Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan… in Cancer & Metabolism (2018)

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  2. Article

    Open Access

    Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors

    The intestinal crypt homeostasis is maintained by a combination of growth factors including Wnt, R-Spondin1, Noggin and the epidermal growth factor (EGF). In human colorectal cancer, the Wnt pathway is constit...

    Kirsten Ludwig, Edison S Tse, Jean YJ Wang in BMC Cancer (2013)

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