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  1. No Access

    Article

    Target accessibility dictates the potency of human RISC

    In this report, we examined the effect of increased target site access on activated human RNA-induced silencing complex (RISC*) catalysis. Kinetic studies revealed that siRNA-programmed RISC* cleaved target RNA w...

    Kirk M Brown, Chia-ying Chu, Tariq M Rana in Nature Structural & Molecular Biology (2005)

  2. No Access

    Article

    Specific and potent RNAi in the nucleus of human cells

    RNA interference (RNAi) has become a research tool to control gene expression in various organisms and holds potential as a new therapeutic strategy. The mechanism of small interfering RNA (siRNA)-mediated RNA...

    G Brett Robb, Kirk M Brown, Jaspreet Khurana… in Nature Structural & Molecular Biology (2005)