Antiviral Agents
Advances and Problems
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Article
Asparagine bioavailability regulates the translation of MYC oncogene
Amino acid restriction has recently emerged as a compelling strategy to inhibit tumor growth. Recent work suggests that amino acids can regulate cellular signaling in addition to their role as biosynthetic sub...
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Article
Adapting to cell stress from inside and out
The ability of cancer cells to adapt to external and internal stresses is critical for tumourigenesis. A new study now shows that the integrated stress response is critical for tumour cell adaptation to stress...
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Article
Open AccessDownregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells
Oxidative stress determines cell fate through several mechanisms, among which regulation of mRNA translation by the phosphorylation of the alpha (α) subunit of the translation initiation factor eIF2α at serine...
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Chapter
7 Regulation of the yeast general amino acid control pathway in response to nutrient stress
In response to starvation for amino acids, yeast cells induce the expression of a collection of genes involved in amino acid metabolism. This pathway referred to as the general amino acid control is a true cro...
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Drug discovery and development of antiviral agents for the treatment of chronic hepatitis B virus infection
A safe and effective vaccine for hepatitis B virus (HBV) has been available for nearly twenty years and currently campaigns to provide universal vaccination in develo** countries are underway. Nevertheless, ...
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The identification and development of antiviral agents for the treatment of chronic hepatitis B virus infection
Hepatitis B virus (HBV) is the leading cause of chronic hepatitis throughout the world. Notwithstanding the availability of a safe and effective vaccine, the world prevalence of HBV has not declined significan...
