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Article
Open AccessModulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiological and psychiatric effects. To elucidate the molecular effects of E2 on the brain, we...
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Article
Open AccessReply to: A balanced measure shows superior performance of pseudobulk methods in single-cell RNA-sequencing analysis
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Article
Open AccessAssessment of label-free quantification and missing value imputation for proteomics in non-human primates
Reliable and effective label-free quantification (LFQ) analyses are dependent not only on the method of data acquisition in the mass spectrometer, but also on the downstream data processing, including software...
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Article
Open AccessSingle-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes
We performed expression quantitative trait locus (eQTL) analysis in single classical (CL) and non-classical (NCL) monocytes from patients with systemic lupus erythematosus (SLE) to quantify the impact of well-...
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Article
miR-181a Mediates Inflammatory Gene Expression After Intracerebral Hemorrhage: An Integrated Analysis of miRNA-seq and mRNA-seq in a Swine ICH Model
Intracerebral hemorrhage (ICH) is a severe neurological disorder with no proven treatment. Inflammation after ICH contributes to clinical outcomes, but the relevant molecular mechanisms remain poorly understo...
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Article
Open AccessHierarchicell: an R-package for estimating power for tests of differential expression with single-cell data
Study design is a critical aspect of any experiment, and sample size calculations for statistical power that are consistent with that study design are central to robust and reproducible results. However, the e...
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Article
Open AccessA practical solution to pseudoreplication bias in single-cell studies
Cells from the same individual share common genetic and environmental backgrounds and are not statistically independent; therefore, they are subsamples or pseudoreplicates. Thus, single-cell data have a hierar...
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Article
Open AccessIntegrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets
Systemic sclerosis (SSc) is a rare autoimmune fibrosing disease with an incompletely understood genetic and non-genetic etiology. Defining its etiology is important to allow the development of effective predic...
