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Article
Open AccessUntargeted serum metabolic profiling of diabetes mellitus among Parkinson’s disease patients
Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson’s disease (PD) patients. Yet, little is known about dysregulated pathways that are unique in PD patients with T2DM. We applied high-resol...
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Article
Open AccessLysosomal genes contribute to Parkinson’s disease near agriculture with high intensity pesticide use
Parkinson’s disease (PD), the second most common neurodegenerative disorder, develops sporadically, likely through a combination of polygenic and environmental factors. Previous studies associate pesticide exp...
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Open AccessDiet and the gut microbiome in patients with Parkinson’s disease
It has been suggested that gut microbiota influence Parkinson’s disease (PD) via the gut–brain axis. Here, we examine associations between diet and gut microbiome composition and its predicted functional pathw...
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Article
Open AccessCorrection to: Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno‑/GrimAge and DNA‑methylation based PAI1
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Open AccessHigher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1
Sex hormones are hypothesized to drive sex-specific health disparities. Here, we study the association between sex steroid hormones and DNA methylation-based (DNAm) biomarkers of age and mortality risk includi...
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Article
Open AccessUntargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson’s disease
Untargeted high-resolution metabolomic profiling provides simultaneous measurement of thousands of metabolites. Metabolic networks based on these data can help uncover disease-related perturbations across inte...
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Article
Open AccessTowards improved screening of toxins for Parkinson’s risk
Parkinson’s disease (PD) is a chronic, progressive and disabling neurodegenerative disorder. The prevalence of PD has risen considerably over the past decades. A growing body of evidence suggest that exposure ...
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Article
Open AccessPan-primate studies of age and sex
Age and sex have a profound effect on cytosine methylation levels in humans and many other species. Here we analyzed DNA methylation profiles of 2400 tissues derived from 37 primate species including 11 haplor...
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Article
Disease risk and healthcare utilization among ancestrally diverse groups in the Los Angeles region
An individual’s disease risk is affected by the populations that they belong to, due to shared genetics and environmental factors. The study of fine-scale populations in clinical care is important for identify...
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Open AccessPublisher Correction: A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides
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Open AccessA pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides
Parkinson’s disease (PD) is a complex neurodegenerative disease with etiology rooted in genetic vulnerability and environmental factors. Here we combine quantitative epidemiologic study of pesticide exposures ...
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Article
Open AccessAccelerated hematopoietic mitotic aging measured by DNA methylation, blood cell lineage, and Parkinson’s disease
Aging and inflammation are important components of Parkinson’s disease (PD) pathogenesis and both are associated with changes in hematopoiesis and blood cell composition. DNA methylation (DNAm) presents a mech...
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Article
Correction to: α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy
A correction to this paper has been published: https://doi.org/10.1007/s00401-021-02332-0
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Open Accessα-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy
The diagnosis of Parkinson’s disease (PD) and atypical parkinsonian syndromes is difficult due to the lack of reliable, easily accessible biomarkers. Multiple system atrophy (MSA) is a synucleinopathy whose sy...
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Open AccessDNA methylation biomarker for cumulative lead exposure is associated with Parkinson’s disease
Lead, a known neurotoxicant, has previously received attention in Parkinson’s disease (PD) research, but epidemiologic studies have been limited in sample size and findings are equivocal. We generated two meth...
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Incidence, gender influence, and neuropsychological predictors of all cause dementia in the Faroe Islands—the Faroese Septuagenarian cohort
Using the Faroese Septuagenarian cohort, we aimed to describe the incidence of dementia and assess the validity of neurocognitive tests to predict subsequent dementia diagnosis.
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Type 2 Diabetes Mellitus and Alzheimer’s Disease: Overlap** Biologic Mechanisms and Environmental Risk Factors
A number of studies over the past two decades have suggested that type 2 diabetes mellitus (T2DM) patients are at an increased risk of Alzheimer’s disease (AD). Several common molecular pathways to cellular an...
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Open AccessParkinson’s disease is associated with DNA methylation levels in human blood and saliva
Several articles suggest that DNA methylation levels in blood relate to Parkinson’s disease (PD) but there is a need for a large-scale study that involves suitable population based controls. The purposes of th...
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Of Pesticides and Men: a California Story of Genes and Environment in Parkinson’s Disease
At the start of the postgenomics era, most Parkinson’s disease (PD) etiology cannot be explained by our knowledge of genetic or environmental factors alone. For more than a decade, we have explored gene–enviro...
