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  1. No Access

    Article

    Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS production

    The activation of receptor-interacting protein kinase 1 (RIPK1) by death-inducing signaling complex (DISC) formation is essential for triggering the necroptotic mode of cell death under apoptosis-deficient con...

    Hee Sun Byun, Eun** Ju, Kyeong Ah Park, Kyung-Cheol Sohn… in Cell Biology and Toxicology (2023)

  2. Article

    Open Access

    Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis

    Plant-derived lignans have numerous biological effects including anti-tumor and anti-inflammatory activities. Screening of purified constituents of Rubia philippinensis from human glioblastoma cells resistant to ...

    So-Ra Lee, Khong Trong Quan, Hee Sun Byun, InWha Park, Kidong Kang… in Scientific Reports (2019)

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  3. No Access

    Article

    Discovery of rubiarbonone C as a selective inhibitor of cytochrome P450 4F enzymes

    Cytochrome P450 (CYP) enzymes, particularly CYP4A/4F, are the major ω-hydroxylases of arachidonic acid (AA) that can produce 20-hydroxyeicosatetraenoic acid (20-HETE). Although there are dissimilarities in sub...

    Yeon Jung Choi, Khong Trong Quan, InWha Park, Seung ** Lee… in Archives of Toxicology (2018)

  4. Article

    Open Access

    Cytotoxic properties of the anthraquinone derivatives isolated from the roots of Rubia philippinensis

    Cancer is one of the most frequently occurring diseases and is the second leading cause of death worldwide. In this study, anthraquinone derivatives (Compounds 1–5) were evaluated for their anti-cancer potenti...

    Vivek K. Bajpai, Md Badrul Alam… in BMC Complementary and Alternative Medicine (2018)

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  5. Article

    Open Access

    Attenuation of inflammatory responses by (+)-syringaresinol via MAP-Kinase-mediated suppression of NF-κB signaling in vitro and in vivo

    We examined the anti-inflammatory effects of (+)-syringaresinol (SGRS), a lignan isolated from Rubia philippinensis, in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells using enzyme-based immuno assay, Western...

    Vivek K. Bajpai, Md Badrul Alam, Khong Trong Quan, Mi-Kyoung Ju… in Scientific Reports (2018)

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  6. Article

    Open Access

    Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38

    The aim of the present study was to examine the antioxidative activity of (+)-lariciresinol (LRSL), an optically active lignan isolated from Rubia philippinensis in several in vitro assays. LRSL was also subjecte...

    Vivek K. Bajpai, Md Badrul Alam, Khong Trong Quan, Kyoo-Ri Kwon… in Scientific Reports (2017)

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