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Reference Work Entry In depth
p75NTR: A Molecule with Multiple Functions in Amyloid-β Metabolism and Neurotoxicity
Alzheimer’s disease (AD) is the most common form of dementia among the elderly. Amyloid-β (Aβ) accumulation and the downstream pathological events, such as neurofibrillary tangles, neuron loss, neurite degener...
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Living Reference Work Entry In depth
p75NTR: A Molecule with Multiple Functions in Amyloid-β Metabolism and Neurotoxicity
Alzheimer’s disease (AD) is the most common form of dementia among the elderly. Amyloid-β (Aβ) accumulation and the downstream pathological events, such as neurofibrillary tangles, neuron loss, neurite degener...
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Article
A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila
Although glucose-sensing neurons were identified more than 50 years ago, the physiological role of glucose sensing in metazoans remains unclear. Here we identify a pair of glucose-sensing neurons with bifurcat...
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Article
Correction to: Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance
The original version of this article unfortunately contained mistake. The old version of Fig. 3 was published.
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Article
Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance
The accumulation of excess intracellular or extracellular amyloid beta (Aβ) is one of the key pathological events in Alzheimer’s disease (AD). Aβ is generated from the cleavage of amyloid precursor protein (AP...
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Article
TREM1: A Potential Therapeutic Target For Alzheimer’s Disease
Immunity has been suggested to play crucial roles in the pathogenesis of Alzheimer’s disease (AD). The triggering receptor expressed on myeloid cells-1 (TREM1), a member of the immunoglobulin superfamily of re...
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Reference Work Entry In depth
p75NTR: A Molecule with Multiple Functions in Amyloid-Beta Metabolism and Neurotoxicity
The p75 neurotrophin receptor (p75NTR) is a pan-receptor for neurotrophins including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin 4/5. P75NTR plays a diverse role fr...
