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Prognostic impact of eosinophils in mastocytosis: analysis of 2350 patients collected in the ECNM Registry

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  1. Article

    Open Access

    KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis

    KIT D816 mutations (KIT D816mut) are strongly associated with systemic mastocytosis (SM) but are also detectable in acute myeloid leukemia (AML), where they represent an adverse prognostic factor in combination w...

    Mohamad Jawhar, Konstanze Döhner, Sebastian Kreil, Juliana Schwaab… in Leukemia (2019)

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  2. Article

    Open Access

    Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model

    While cancer stem cells are well established in certain hematologic and solid malignancies, their existence in T cell lymphoma is unclear and the origin of disease is not fully understood. To examine the exist...

    Stefanie Kreutmair, Cathrin Klingeberg, Teresa Poggio, Geoffroy Andrieux… in Leukemia (2020)

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  3. Article

    Open Access

    Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model

    The persistence of leukemic stem cells (LSCs) represents a problem in the therapy of chronic myeloid leukemia (CML). Hence, it is of utmost importance to explore the underlying mechanisms to develop new therap...

    Melanie Langhammer, Julia Schöpf, Timo Jaquet, Katharina Horn, Moritz Angel… in Leukemia (2023)

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  4. Article

    Open Access

    Allogeneic Hematopoietic Cell Transplantation in Advanced Systemic Mastocytosis: A retrospective analysis of the DRST and GREM registries

    We identified 71 patients with AdvSM (aggressive SM [ASM], SM with an associated hematologic neoplasm [SM-AHN, e.g., acute myeloid leukemia, SM-AML], mast cell leukemia [MCL]) in two national registries (DRST/...

    Johannes Lübke, Deborah Christen, Juliana Schwaab, Anne Kaiser, Nicole Naumann… in Leukemia (2024)

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