Orphan Lung Diseases
A Clinical Guide to Rare Lung Disease
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Transkingdom Network Analysis (TkNA): a systems framework for inferring causal factors underlying host–microbiota and other multi-omic interactions
We present Transkingdom Network Analysis (TkNA), a unique causal-inference analytical framework that offers a holistic view of biological systems by integrating data from multiple cohorts and diverse omics typ...
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Open AccessAuthor Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma
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Rheumatoid Arthritis and the Lungs
Rheumatoid arthritis (RA) is a common autoimmune disease affecting approximately 0.5% of the global population. All compartments of the respiratory system can be involved with interstitial lung disease (ILD), ...
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Interstitial Pneumonia with Autoimmune Features
A 45-year-old woman, never smoker, presents with a slowly progressive dyspnea and also reports a dry cough that is worse with exertion. On symptom review, she reports several months of puffiness of the hands b...
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Open AccessThe behaviour of metals in deep fluids of NE Iceland
In this contribution, we present some of the first data on the elemental signature of deep crustal fluids in a basalt-hosted, low-chloride magmatic-hydrothermal system. Down-hole fluid samples (850–1600 m) fro...
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Open AccessCharacterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma
Pediatric medulloblastoma (MB) is the most common solid malignant brain neoplasm, with Group 3 (G3) MB representing the most aggressive subgroup. MYC amplification is an independent poor prognostic factor in G3 M...
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Open AccessMepolizumab-Induced Posterior Reversible Encephalopathy Syndrome (PRES), a new patient report
Posterior Reversible Encephalopathy Syndrome (PRES) is a neurotoxic state characterized by seizures, headache, vision change, paresis, and altered mental status. PRES has an important place in medicine due to ...
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Open AccessExtended interval BNT162b2 vaccination enhances peak antibody generation
The BNT162b2 vaccine is highly effective against COVID-19 infection and was delivered with a 3-week time interval in registration studies1. However, many countries extended this interval to accelerate population ...
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Open AccessTwo-phase survey on the frequency of use and safety of MRI for hearing implant recipients
Magnetic resonance imaging (MRI) is often used to visualize and diagnose soft tissues. Hearing implant (HI) recipients are likely to require at least one MRI scan during their lifetime. However, the MRI scanne...
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Open AccessThe ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
Acute myeloid leukemia (AML) remains incurable, largely due to its resistance to conventional treatments. Here, we find that increased abundance of the ubiquitin ligase RNF5 contributes to AML development and ...
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Open AccessDifferential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people
Several SARS-CoV-2 vaccines have shown clinical efficacy against Covid-19 infection but there remains uncertainty about the immune responses elicited by different regimens. This is a particularly important que...
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Author Correction: Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection
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Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection
The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern that waning immunity may predispose to reinfection. We analyzed the magnitude and phenotype of the SARS-CoV-2-specific...
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Open AccessSustainable forest biomass: a review of current residue harvesting guidelines
Forest biomass harvesting guidelines help ensure the ecological sustainability of forest residue harvesting for bioenergy and bioproducts, and hence contribute to social license for a growing bioeconomy. Guide...
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Open AccessSiah2 control of T-regulatory cells limits anti-tumor immunity
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete reject...
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Endovascular Management of Cervical Vascular Trauma
Traumatic vascular injuries involving the carotid and vertebral arteries can be some of the most difficult injuries to diagnose and treat. Blunt injuries frequently result in asymptomatic periods with little t...
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DXA-equivalent quantification of bone mineral density using dual-layer spectral CT scout scans
To develop and evaluate a method for areal bone mineral density (aBMD) measurement based on dual-layer spectral CT scout scans.
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Open AccessGut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice
Accumulating evidence points to an important role for the gut microbiome in anti-tumor immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, limiting tumor expansion. M...
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Battle of the bots: a comparison of the standard da Vinci and the da Vinci Surgical Skills Simulator in surgical skills acquisition
Virtual reality simulators are increasingly used to gain robotic surgical skills. This study compared use of the da Vinci Surgical Skills Simulator (dVSSS) to the standard da Vinci (SdV) robot for skills acqui...
