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Article
Open AccessThe long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis
Although patients with rheumatoid arthritis (RA) typically exhibit symmetrical joint involvement, some patients develop alternative disease patterns in response to treatment, suggesting that different molecula...
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Article
Open AccessThe histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels
The activation of stress response pathways in synovial fibroblasts (SF) is a hallmark of rheumatoid arthritis (RA). CBP and p300 are two highly homologous histone acetyl transferases and writers of activating ...
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Article
Open AccessFunctional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability
Genome-wide association studies have reported more than 100 risk loci for rheumatoid arthritis (RA). These loci are shown to be enriched in immune cell-specific enhancers, but the analysis so far has excluded ...
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Article
Open AccessEvaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis
Targeting epigenetic reader proteins by small molecule inhibitors represents a new therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although inhibitors targeting bromodomain protei...
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Article
Epigenetics in the pathogenesis of RA
Epigenetic modifications can stably alter gene expression and have been shown to be important in the maintenance of cell type-specific functions as well as in cell differentiation, e.g., in T and B cell matura...
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Article
Open AccessEpigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show transcriptomic differences in synovial fibroblasts from differ...
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Article
SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts
Cigarette smoking is a recognized environmental risk factor for the development and progression of rheumatoid arthritis (RA). RA synovial fibroblasts (RASF) actively contribute to inflammation and joint destru...
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Article
Epigenetic contributions in the development of rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation of the joints with severe pain and swelling, joint damage and disability, which leads to joint destruction and loss of ...
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Article
7th meeting of the global arthritis research network
Last October, the 7th meeting of the Global Arthritis Research Network was held in Zurich, Switzerland. European and American experts who have made major recent contributions to molecular biology got together ...
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Article
Quantitative vibronic coupling calculations: the formyloxyl radical
The performance of different choices of parametrization for the quasidiabatic Hamiltonian approach of Köppel et al. (Adv Chem Phys 57:59, 1984) is studied for the
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Der Mißbrauch der Figur des Eingehungsbetruges in der höchstrichterlichen Rechtsprechung als Instrument der Strafbarkeitsbegründung
Die Konstruktion des Eingehungsbetruges ist seit den Anfängen der reichsgerichtlichen Entscheidungspraxis Bestandteil der höchstrichterlichen Rechtsprechung; so findet sich die Dogmatik des Eingehungs- und auc...
