10 Result(s)
within
Kentaro Yamada
Biomedicine
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Article
Open AccessStress-induced galectin-1 influences immune tolerance in the spleen and thymus by modulating CD45 immunoreactive lymphocytes
Galectin-1 (Gal-1) is differentially expressed in normal and pathological tissues and regulates immune cell homeostasis. Restraint stress increases serum Gal-1 in rats. However, the function of stress-induced ...
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Article
Increased pathogenicity of rabies virus due to modification of a non-coding region
Sub-passaging of QS-05, a street rabies virus (RABV) isolate, in non-neuronal cells resulted in a virus with higher pathogenicity, QS-BHK-P7. Four full-length cDNA plasmids were constructed and the correspondi...
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Article
Characterization of street rabies virus variants with an additional N-glycan at position 247 in the glycoprotein
Most street rabies virus glycoproteins (G proteins) possess two N-glycosylation sites, at Asn37 and Asn319, whereas an additional N-glycosylation site is present in several fixed (laboratory-adapted) rabies virus...
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Article
Molecular analysis of the mutational effects of Thai street rabies virus with increased virulence in mice after passages in the BHK cell line
QS-BHK-P7, street rabies virus, after passages in the BHK cell line, had an in vitro phenotype that distinguished it from its parental virus. Both viruses caused lethal infection in mice by central nervous system...
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Article
Whole-genome analysis of a human rabies virus from Sri Lanka
The complete genome sequence of a human rabies virus, strain H-08-1320, from Sri Lanka was determined and compared with other rabies viruses. The size of the genome was 11,926 nt, and it was composed of a 58-n...
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Article
Determination of the 5′-terminal sequence of subgenomic RNA of hepatitis E virus strains in cultured cells
Using RNA preparations extracted from PLC/PRF/5 cells transfected with infectious genotype 3 hepatitis E virus (HEV) cDNA clones or inoculated with a fecal suspension containing a genotype 4 HEV, the 5′-termin...
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Article
INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese
The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this associati...
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Article
Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces
Ten murine monoclonal antibodies (MAbs) against a synthetic peptide corresponding to the well-conserved, C-terminal 24-amino acid portion of ORF3 protein of hepatitis E virus (HEV) were produced and characteri...
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Article
Variations in the FTO gene are associated with severe obesity in the Japanese
Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To i...
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Article
Region at amino acids 164 to 303 of the rabies virus glycoprotein plays an important role in pathogenicity for adult mice
The authors have previously reported that the glycoprotein of the pathogenic Nishigahara strain of rabies virus is required to lethality for adult mice. A cluster region of amino acid substitutions exists at t...
