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Article
Open AccessIntegrative analysis reveals early epigenetic alterations in high-grade serous ovarian carcinomas
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological malignancy. To date, the profiles of gene mutations and copy number alterations in HGSOC have been well characterized. However, the ...
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Article
Open AccessCase study of the convergent evolution in the color patterns in the freshwater bivalves
The class Bivalvia (phylum Mollusca) is one of the most successful at survival groups of animals with diverse color patterns on their shells, and they are occasionally preserved in the fossil record as residua...
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Article
Role of dipyridyl disulfide cross-linking moieties in an acrylate photo-adhesive material
2,2’-Dipyridyl disulfide moiety is introduced into a UV-cured photo-adhesive material, as a diacrylate cross-linking reagent. Radical UV curing is performed with the cross-linking reagent, 2-hydroxyethyl acryl...
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Article
Open AccessP16INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway
Previous studies have largely failed to clarify the relationship between p16INK4A status and cervical adenocarcinoma prognosis. The current study aimed to examine the clinical and pathological significance of p16
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Article
Open AccessNeutropenic enterocolitis-induced sepsis and disseminated intravascular coagulation after chemotherapy: a case report
Neutropenic enterocolitis (NE) is a potentially life-threatening disease that primarily occurs in cancer patients treated with chemotherapy. NE has substantial morbidity and mortality, and its incidence has in...
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Article
Open AccessPathological findings in the endometrium after microwave endometrial ablation
The acceptance of MEA in Japan is well demand due to its outstanding effectiveness and safety. Infrequently, a repeat MEA or hysterectomy is needed for recurrent menorrhagia in case of failure ablation. The re...
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Article
Open AccessComparison between bidirectional Stratafix® barbed suture and conventional suture in laparoscopic myomectomy: a retrospective study
Laparoscopic myomectomy (LM) is one of the techniques feasible for the treatment of intramural myoma. This technique is reported to be difficult when large fibroids are involved because of excessive blood loss...
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Article
Open AccessMucinous borderline ovarian tumors with BRAFV600E mutation may have low risk for progression to invasive carcinomas
Mucinous ovarian carcinomas (MOCs) are relatively rare. It has been proposed that a subset of mucinous cystadenomas (MCAs) may progress to mucinous borderline tumors (MBTs), and then to MOCs. KRAS is the predomin...
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Article
Open AccessHigh PD-1 expression level is associated with an unfavorable prognosis in patients with cervical adenocarcinoma
The effectiveness of immunotherapy for cervical adenocarcinoma (CA) has not been demonstrated yet. Programmed cell death 1 (PD-1), programmed cell death-ligand 1 (PD-L1), and CD8 may be used as biomarkers of r...
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Article
Open AccessA case with life-threatening uterine bleeding due to postmenopausal uterine arteriovenous malformation
Uterine arteriovenous malformation is a rare but life-threatening condition that accounts for 1–2% of massive vaginal bleeding. Uterine arteriovenous malformations are less common after menopause. The conditio...
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Article
Sister Mary Joseph’s nodule associated with rare endometrial squamous cell carcinoma
Umbilical metastasis (Sister Mary Joseph’s nodule) is a rare physical sign seen only in 1–3 % of patients with an intra-abdominal and/or pelvic malignancy. Here, we present a case of Sister Mary Joseph’s (SMJN...
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Article
Evaluation of immediate laparoscopic surgery for gynecologic disorders
The purpose of this study was to obtain information to aid in deciding the timing of immediate laparoscopic surgery for gynecological disorders. We evaluated immediate laparoscopic surgery (within 12 h after a...
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Article
MKK4 acts as a potential tumor suppressor in ovarian cancer
Our previous studies indicate that loss of MKK4 expression is associated with the progression of ovarian cancer. However, direct evidence that MKK4 inhibits the malignant phenotype of ovarian cancer cells is l...
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Article
Microwave endometrial ablation is a highly efficacious way to emergently control life-threatening uterine hemorrhage
To asses the effectiveness of microwave endometrial ablation (MEA) using a new curved applicator for the emergent control of uterine hemorrhage.
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Article
Concomitant postoperative radiation and chemotherapy following surgery was associated with improved overall survival in patients with FIGO stages III and IV endometrial cancer
The aim of this study was to investigate the usefulness of concomitant postoperative radiation and chemotherapy in patients with the International Federation of Gynecology and Obstetrics (FIGO) stages III and ...
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Article
Potential of the Ultra-thin Layer Fabricated by Wet-process as a Pore-Seal for Porous Low-k Films
We succeeded in fabricating ultra-thin (<3 nm-thick) layer on top of the surface of porous low-k. The roughness of the surface of porous low-k remains homogeneous even after covering by the thin layer. Furthermor...
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Article
Prolonged long-term survival of low-grade endometrial stromal sarcoma patients with lung metastasis following treatment with medroxyprogesterone acetate
The aim of this study was to investigate the usefulness of medroxyprogesterone acetate (MPA) therapy for patients with metastatic low-grade endometrial stromal sarcoma (LGESS).
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Article
A case of bilateral pelvic lymph node involvement in stage 1a1 squamous cell carcinoma of cervix and a review of the literature
Stage1a1 cervical cancer has been established to define a subset of the disease in patients who may safely be managed more conservatively and who have an excellent prognosis. Recently, however, a number of sta...
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Article
Open AccessMicrowave endometrial ablation as an alternative to hysterectomy for the emergent control of uterine bleeding in patients who are poor surgical candidates
Microwave endometrial ablation is a new, minimally invasive treatment option for menorrhagia. Its popularity in many countries is increasing due to its safety and simplicity.
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Article
Primary osteosarcoma of ovary
Primary osteosarcoma originating from the ovary is an exceedingly rare, highly malignant tumor. Only a few cases have been reported in the past few decades. We describe a 50-year-old postmenopausal woman who p...
