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Article
Open AccessClinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis
Ancient schwannoma (AS) is a subtype of schwannoma characterized by slow progression despite degenerative changes in pathology. Although it is considered a benign tumor, most previous reports have focused on e...
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Article
Open AccessMeningiomas in patients with neurofibromatosis type 2 predominantly comprise ‘immunogenic subtype’ tumours characterised by macrophage infiltration
Although recent molecular analyses revealed that sporadic meningiomas have various genetic, epigenetic, and transcriptomic profiles, meningioma in patients with neurofibromatosis type 2 (NF2) have not been ful...
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Article
Open AccessComplex evolution of the 2016 Kaikoura earthquake revealed by teleseismic body waves
The 2016 Kaikoura earthquake, New Zealand, ruptured more than a dozen faults, making it difficult to prescribe a model fault for analyzing the event by inversion. To model this earthquake from teleseismic reco...
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Article
Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study
The genetic background of intracranial artery stenosis (ICAS), a major cause of ischemic stroke, remains elusive. We performed the world’s first genome-wide association study (GWAS) of ICAS using DNA samples f...
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Article
Open AccessSomatic GJA4 gain-of-function mutation in orbital cavernous venous malformations
Orbital cavernous venous malformation (OCVM) is a sporadic vascular anomaly of uncertain etiology characterized by abnormally dilated vascular channels. Here, we identify a somatic missense mutation, c.121G > ...
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Article
Correction to: RNF213 p.Arg4810Lys Heterozygosity in Moyamoya Disease Indicates Early Onset and Bilateral Cerebrovascular Events
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Article
Open AccessEarly prediction of functional prognosis in neurofibromatosis type 2 patients based on genotype–phenotype correlation with targeted deep sequencing
Regardless of treatment, the clinical progression of neurofibromatosis type 2 (NF2), particularly in terms of hearing, swallowing, and gait, tend to worsen throughout the patients’ lives. We performed a retros...
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Article
RNF213 p.Arg4810Lys Heterozygosity in Moyamoya Disease Indicates Early Onset and Bilateral Cerebrovascular Events
The relationship between RNF213 c.14429G > A (p.Arg4810Lys) heterozygous variants and clinical manifestation in patients with Moyamoya disease (MMD) remains unclear. We performed a retrospective cohort analysis t...
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Article
Open AccessClinical significance of NF2 alteration in grade I meningiomas revisited; prognostic impact integrated with extent of resection, tumour location, and Ki-67 index
NF2 alteration is the most commonly–found genetic abnormality in meningiomas and is known to initiate events for aggressive-type meningiomas. Whereas the prognosis of meningiomas differs depending on their epigen...
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Article
Open AccessBrainstem intraparenchymal schwannoma with genetic analysis: a case report and literature review
Schwannomas are neoplasms that typically arise from the myelin sheath of peripheral nerves and rarely originate within the brain parenchyma. Some case reports present schwannomas arising from the brainstem, bu...
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Article
Technique for rerouting a bridging vein that hinders the anterior interhemispheric approach: a technical note
The frontal bridging vein, which is the venous drainage route of the frontal cortex into the superior sagittal sinus (SSS), sometimes poses an obstacle in the anterior interhemispheric approach during surgery ...
