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Article
Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients
The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging. However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the accuracy of distinguishing tumou...
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Article
Portal Vein or Superior Mesenteric Vein Thrombosis with Dose-Escalated Radiation for Borderline or Locally Advanced Pancreatic Cancer
Portal vein and superior mesenteric vein thrombosis (PVT/SMVT) are potentially morbid complications of radiation dose–escalated local therapy for pancreatic cancer. We retrospectively reviewed records for pati...
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Correction to: Oncolytic HSV1 targets different growth phases of breast cancer leptomeningeal metastases
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Article
Oncolytic HSV1 targets different growth phases of breast cancer leptomeningeal metastases
Leptomeningeal metastasis is a fatal complication of breast cancer which results when cancer cells seed in the meninges. Currently there is no cure, limiting survival to less than four months. Treatment option...
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Article
Open AccessA human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
Chronic liver disease and hepatocellular carcinoma (HCC) are life-threatening diseases with limited treatment options. The lack of clinically relevant/tractable experimental models hampers therapeutic discover...
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Open AccessAuthor Correction: Quantitative, noninvasive MRI characterization of disease progression in a mouse model of non-alcoholic steatohepatitis
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Article
Hepatectomy for Solitary Hepatocellular Carcinoma: Resection Margin Width Does Not Predict Survival
The survival benefit of negative margins for hepatocellular carcinoma (HCC) has been demonstrated. However, there is no consensus regarding the optimal resection margin width. We assessed the impact of hepatic...
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Article
Open AccessQuantitative, noninvasive MRI characterization of disease progression in a mouse model of non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) is an increasing cause of chronic liver disease characterized by steatosis, inflammation, and fibrosis which can lead to cirrhosis, hepatocellular carcinoma, and mortality....
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Article
Collagen-targeted molecular imaging in diffuse liver diseases
Liver fibrosis is a common pathway shared by all progressive chronic liver diseases (CLD) regardless of the underlying etiologies. With liver biopsy being the gold standard in assessing fibrosis degree, there ...
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Article
Management implications of fluorodeoxyglucose positron emission tomography/magnetic resonance in untreated intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is associated with a poor prognosis with surgical resection offering the best chance for long-term survival and potential cure. However, in up to 36% of patients who under...
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Chapter
Hyperthermic Isolated Limb Perfusion for Melanoma
In-transit melanoma metastases arise from lymphatic spread and growth in relative proximity to the primary melanoma. When confined to an extremity, in-transit metastases are effectively treated with hypertherm...
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Reference Work Entry In depth
Local and Recurrent Regional Metastases of Melanoma
Up to 10% of patients with cutaneous melanoma will develop recurrent locoregional disease. While surgical resection remains the mainstay of treatment for isolated recurrences, locoregional melanoma can often p...
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Article
Hepatocellular Carcinoma in Transplantable Child-Pugh A Cirrhotics: Should Cost Affect Resection vs Transplantation?
There is no consensus regarding the optimal surgical treatment for transplantable hepatocellular carcinoma (HCC) patients with well-compensated cirrhosis. Our aim was to compare outcomes between Child-Pugh A (...
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Article
A model of breast cancer meningeal metastases: characterization with in vivo molecular imaging
Meningeal metastasis is a fatal complication of breast cancer which affects 8–15% of patients who experience severe neurological complications of cranial nerves, cerebrum, and spinal cord. Survival once diagno...
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Chapter
Prevention Strategies for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) occurs primarily in patients who have sustained years of chronic liver injury. Unfortunately, most patients are diagnosed with advanced disease when potentially curative surgical...
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Living Reference Work Entry In depth
Local and Recurrent Regional Metastases of Melanoma
Up to 10% of patients with cutaneous melanoma will develop recurrent locoregional disease. While surgical resection remains the mainstay of treatment for isolated recurrences, locoregional melanoma can often p...
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Article
Prognostic Significance of Surgical Margin Size After Neoadjuvant FOLFOX and/or FOLFIRI for Colorectal Liver Metastases
Optimal margin size when resecting colorectal liver metastases (CRLM) remains unclear, particularly in the setting of perioperative chemotherapy. We evaluated the prognostic significance of margin size in pati...
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Article
Open AccessTricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells
Activation of hepatic stellate cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by trans-differentiation of quiescent HSCs to HSC myofibroblasts, which secrete extrace...
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Article
Open AccessExtracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver
Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinoge...
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Article
Gallbladder Lesions Identified on Ultrasound. Lessons from the Last 10 Years
Possible mass lesions identified on ultrasound (US) of the gallbladder may prompt an aggressive surgical intervention due to the possibility of a malignant neoplasm.
