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Article
Open AccessLong-term viable chimeric nephrons generated from progenitor cells are a reliable model in cisplatin-induced toxicity
Kidney organoids have shown promise as evaluation tools, but their in vitro maturity remains limited. Transplantation into adult mice has aided in maturation; however, their lack of urinary tract connection li...
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Article
Open AccessGreen leaf volatile sensory calcium transduction in Arabidopsis
Plants perceive volatile organic compounds (VOCs) released by mechanically- or herbivore-damaged neighboring plants and induce various defense responses. Such interplant communication protects plants from envi...
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Article
Open AccessGeneral public’s understanding of rare diseases and their opinions on medical resource allocation in Japan: a cross-sectional study
Rare diseases (RDs) may impose a considerable financial burden on patients and their families. Public acceptance is essential to ensure sustainable public systems supporting RDs, especially in countries with u...
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Article
Open AccessPossible contribution of phosphate to the pathogenesis of chronic kidney disease in dolphins
This study aimed to investigate whether phosphate contributes to the pathogenesis of chronic kidney disease (CKD) in dolphins. Renal necropsy tissue of an aged captive dolphin was analyzed and in vitro experim...
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Article
Open AccessIdentification of a tomato UDP-arabinosyltransferase for airborne volatile reception
Volatiles from herbivore-infested plants function as a chemical warning of future herbivory for neighboring plants. (Z)-3-Hexenol emitted from tomato plants infested by common cutworms is taken up by uninfested p...
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Article
A genome-wide association study on adherence to low-carbohydrate diets in Japanese
Low-carbohydrate diets (LCD) are useful for weight reduction, and 50–55% carbohydrate consumption is associated with minimal risk. Genetic differences were related to nutritional consumption, food preferences,...
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Article
1-Octen-3-ol is formed from its primeveroside after mechanical wounding of soybean leaves
Hydrolysis of 1-octen-3-yl β-primeveroside implemented by a system with high structure-specificity is accountable for the rapid formation of 1-octen-3-ol from soybean leaves after mechanical wounding.
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Article
Public Attitudes toward COVID-19 Vaccinations before Dawn in Japan: Ethics and Future Perspectives
Improving public understanding and acceptance are critical for promoting coronavirus (COVID-19) vaccination. However, how to promote COVID-19 vaccine programs remains controversial due to various ethical issue...
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Article
Open AccessAcquired aplastic anemia complicated with anti-glomerular basement membrane disease successfully treated with immunosuppressive therapy: a case report
Aplastic anemia (AA) is a rare but fatal disorder characterized by pancytopenia due to bone marrow hypoplasia. Anti-glomerular basement membrane disease (anti-GBM disease) is an immune complex small-vessel vas...
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Article
Open AccessRelationship of leisure-time and household physical activity level and type with cardiovascular disease: secondary analysis of the Takashima Study data
High levels of participation in leisure-time and household physical activity lower the risk of cardiovascular disease (CVD), although it is unclear whether the number of activity types is related to new-onset ...
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Chapter and Conference Paper
Development of Mobile Device-Based Speech Enhancement System Using Lip-Reading
We have been develo** a speech enhancement device for laryngectomees. Our approach is to use a lip-reading technology to be able to recognize Japanese words from lip images and generate speech outputs using ...
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Chapter
Pseudoscience During the COVID-19 Pandemic
The COVID-19 pandemic remarkably changed the landscape of scientific research. Preprint and open-access publication culture has been accelerated, low-quality research has been disseminated, and scientists have...
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Book and Conference Proceedings
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Article
Open AccessA systematic approach to the disclosure of genomic findings in clinical practice and research: a proposed framework with colored matrix and decision-making pathways
Whether and how to disclose genomic findings obtained in the course of genomic clinical practice and medical research has been a controversial global bioethical issue over the past two decades. Although severa...
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Article
Open AccessA Proposed Model of Core Competencies for Research Ethics Consultants
Research ethics consultation services (RECS), which function as an advisory service to facilitate the resolution of complex ethical issues in clinical research, have been proliferating over the last decade. Ho...
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Article
A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern
Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of ...
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Article
Open AccessRenal hemosiderosis presenting with acute kidney Injury and macroscopic hematuria in Immunoglobulin A nephropathy: a case report
Macroscopic hematuria-associated acute kidney injury (AKI) is a well-known complication of immunoglobulin A (IgA) nephropathy. In such cases, intratubular obstruction by red blood cell (RBC) casts and acute tu...
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Article
Open AccessAn educational workshop designed for research ethics consultants to educate investigators on ethical considerations
The role of research ethics consultants in biomedical research has increased to the point that they have an advisory capacity at all research institutes. For such professionals, we have established an educatio...
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Article
A genome-wide association study on fish consumption in a Japanese population—the Japan Multi-Institutional Collaborative Cohort study
Although benefits of fish consumption for health are well known, a significant percentage of individuals dislike eating fish. Fish consumption may be influenced by genetic factors in addition to environmental ...
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Article
Peritoneal dialysis-related peritonitis complicated with nonocclusive mesenteric ischemia
Peritoneal dialysis (PD)-related peritonitis is a common complication of PD. Nonocclusive mesenteric ischemia (NOMI) is a rare complication of PD-related peritonitis, has a high mortality rate, and therefore s...
