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Article
RITS acts in cis to promote RNA interference–mediated transcriptional and post-transcriptional silencing
RNA interference is a conserved mechanism by which double-stranded RNA is processed into short interfering RNAs (siRNAs) that can trigger both post-transcriptional and transcriptional gene silencing. In fissio...
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Article
Host genome surveillance for retrotransposons by transposon-derived proteins
Transposable elements and their remnants constitute a substantial fraction of eukaryotic genomes. Host genomes have evolved defence mechanisms, including chromatin modifications and RNA interference, to regula...
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Article
The human Pol III transcriptome and gene information flow
In this issue, three papers report the distribution of the RNA polymerase III (Pol III) machinery, including transcription factor IIIB, transcription factor IIIC and Pol III itself, across the human genome. Th...
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Protocol
Chromatin Immunoprecipitation to Detect DNA Replication and Repair Factors
DNA replication is tightly coupled with DNA repair processes in order to preserve genomic integrity. During DNA replication, the replication fork encounters a variety of obstacles including DNA damage/adducts,...
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Article
Transcription factors mediate condensin recruitment and global chromosomal organization in fission yeast
Ken-ichi Noma and colleagues use ChIA-PET to identify genome-wide associations mediated by condensin and cohesin in fission yeast. They find that cohesin and condensin generate small and larger chromatin domai...
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Article
Condensin-mediated chromosome organization in fission yeast
Genome/chromosome structures are formed by a hierarchy of organizing processes ranging from gene interactions to chromosome territory formation. The SMC complex, cohesin, mediates interactions among enhancers ...
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Article
Architectural alterations of the fission yeast genome during the cell cycle
Analysis of the 3D genomic organization of Schizosaccharomyces pombe during the cell cycle reveals that condensin mediates formation of large domains that serve as chromosomal compaction units, whereas cohesin fo...
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Article
NAD+ metabolism governs the proinflammatory senescence-associated secretome
Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-a...
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Article
Open AccessInvolvement of condensin in cellular senescence through gene regulation and compartmental reorganization
Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompanied by ...
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Article
Open AccessEpigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus
Epstein-Barr virus (EBV) genomes persist in latently infected cells as extrachromosomal episomes that attach to host chromosomes through the tethering functions of EBNA1, a viral encoded sequence-specific DNA ...
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Article
Open AccessMETTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence
METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m6A modification to regulate gene expression. In addition, METTL3 regulates transcription in an enzymatic activity-independent mann...
